Brain amines in fever and sleep cycle changes caused by streptococcal mucopeptide
Intravenous injection of streptococcal mucopeptide 2mg/kg to rats is followed by a marked temperature elevation and a significant decrease of paradoxical sleep. The measurement of turnover rates of 5-hydroxytryptamine and noradrenaline in hypothalamus and midbrain, areas involved in temperature and...
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| Veröffentlicht in: | Neuropharmacology 1973-11, Vol.12 (11), p.1039-1047 |
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| container_title | Neuropharmacology |
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| creator | Masek, K Kadlecová, O Rasková, H |
| description | Intravenous injection of streptococcal mucopeptide 2mg/kg to rats is followed by a marked temperature elevation and a significant decrease of paradoxical sleep. The measurement of turnover rates of 5-hydroxytryptamine and noradrenaline in hypothalamus and midbrain, areas involved in temperature and sleep control, demonstrated a significant increase of 5-hydroxytryptamine turnover in both areas during the fever and paradoxical sleep deprivation. This suggests the activation of 5-hydroxytryptamine neurones and brings further support to the concept relating the indole amines to temperature and sleep regulation. |
| doi_str_mv | 10.1016/0028-3908(73)90048-8 |
| format | Article |
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The measurement of turnover rates of 5-hydroxytryptamine and noradrenaline in hypothalamus and midbrain, areas involved in temperature and sleep control, demonstrated a significant increase of 5-hydroxytryptamine turnover in both areas during the fever and paradoxical sleep deprivation. This suggests the activation of 5-hydroxytryptamine neurones and brings further support to the concept relating the indole amines to temperature and sleep regulation.</description><identifier>ISSN: 0028-3908</identifier><identifier>EISSN: 1873-7064</identifier><identifier>DOI: 10.1016/0028-3908(73)90048-8</identifier><identifier>PMID: 4768638</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Biogenic Amines - metabolism ; Body Temperature - drug effects ; Electrodes, Implanted ; Electromyography ; Fever - metabolism ; Hypothalamus - metabolism ; Kinetics ; Male ; Mesencephalon - metabolism ; Norepinephrine - metabolism ; Pargyline - metabolism ; Peptides - pharmacology ; Rats ; Salicylates - pharmacology ; Serotonin - metabolism ; Sleep - drug effects ; Streptococcus ; Time Factors</subject><ispartof>Neuropharmacology, 1973-11, Vol.12 (11), p.1039-1047</ispartof><rights>1973</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-b01fe940358602be76bdfb552682832c3036eb6db9a88174c7e5f0764eae7e993</citedby><cites>FETCH-LOGICAL-c357t-b01fe940358602be76bdfb552682832c3036eb6db9a88174c7e5f0764eae7e993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0028390873900488$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4768638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masek, K</creatorcontrib><creatorcontrib>Kadlecová, O</creatorcontrib><creatorcontrib>Rasková, H</creatorcontrib><title>Brain amines in fever and sleep cycle changes caused by streptococcal mucopeptide</title><title>Neuropharmacology</title><addtitle>Neuropharmacology</addtitle><description>Intravenous injection of streptococcal mucopeptide 2mg/kg to rats is followed by a marked temperature elevation and a significant decrease of paradoxical sleep. The measurement of turnover rates of 5-hydroxytryptamine and noradrenaline in hypothalamus and midbrain, areas involved in temperature and sleep control, demonstrated a significant increase of 5-hydroxytryptamine turnover in both areas during the fever and paradoxical sleep deprivation. This suggests the activation of 5-hydroxytryptamine neurones and brings further support to the concept relating the indole amines to temperature and sleep regulation.</description><subject>Animals</subject><subject>Biogenic Amines - metabolism</subject><subject>Body Temperature - drug effects</subject><subject>Electrodes, Implanted</subject><subject>Electromyography</subject><subject>Fever - metabolism</subject><subject>Hypothalamus - metabolism</subject><subject>Kinetics</subject><subject>Male</subject><subject>Mesencephalon - metabolism</subject><subject>Norepinephrine - metabolism</subject><subject>Pargyline - metabolism</subject><subject>Peptides - pharmacology</subject><subject>Rats</subject><subject>Salicylates - pharmacology</subject><subject>Serotonin - metabolism</subject><subject>Sleep - drug effects</subject><subject>Streptococcus</subject><subject>Time Factors</subject><issn>0028-3908</issn><issn>1873-7064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAQgIMo67r6DxRyEj1Uk6ZN0ougiy9YEEHPIY-pRvoyaRf239u6i0dPM8N8M8N8CJ1SckUJ5deEpDJhBZEXgl0WhGQykXtoTqVgiSA820fzP-QQHcX4RSaIyhmaZYJLzuQcvd4F7Rusa99AxGNWwhoC1o3DsQLosN3YCrD91M3HCFg9RHDYbHDsA3R9a1trdYXrwbbdWHsHx-ig1FWEk11coPeH-7flU7J6eXxe3q4Sy3LRJ4bQEoqMsFxykhoQ3LjS5HnKZSpZahlhHAx3ptBSUpFZAXlJBM9Ag4CiYAt0vt3bhfZ7gNir2kcLVaUbaIeoZEoZl4SNYLYFbWhjDFCqLvhah42iRE0m1aRJTZqUYOrXpJLj2Nlu_2BqcH9DO3Vj_2bbh_HJtYegovXQWHA-gO2Va_3_B34Adx-CRg</recordid><startdate>197311</startdate><enddate>197311</enddate><creator>Masek, K</creator><creator>Kadlecová, O</creator><creator>Rasková, H</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197311</creationdate><title>Brain amines in fever and sleep cycle changes caused by streptococcal mucopeptide</title><author>Masek, K ; Kadlecová, O ; Rasková, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-b01fe940358602be76bdfb552682832c3036eb6db9a88174c7e5f0764eae7e993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Biogenic Amines - metabolism</topic><topic>Body Temperature - drug effects</topic><topic>Electrodes, Implanted</topic><topic>Electromyography</topic><topic>Fever - metabolism</topic><topic>Hypothalamus - metabolism</topic><topic>Kinetics</topic><topic>Male</topic><topic>Mesencephalon - metabolism</topic><topic>Norepinephrine - metabolism</topic><topic>Pargyline - metabolism</topic><topic>Peptides - pharmacology</topic><topic>Rats</topic><topic>Salicylates - pharmacology</topic><topic>Serotonin - metabolism</topic><topic>Sleep - drug effects</topic><topic>Streptococcus</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masek, K</creatorcontrib><creatorcontrib>Kadlecová, O</creatorcontrib><creatorcontrib>Rasková, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masek, K</au><au>Kadlecová, O</au><au>Rasková, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain amines in fever and sleep cycle changes caused by streptococcal mucopeptide</atitle><jtitle>Neuropharmacology</jtitle><addtitle>Neuropharmacology</addtitle><date>1973-11</date><risdate>1973</risdate><volume>12</volume><issue>11</issue><spage>1039</spage><epage>1047</epage><pages>1039-1047</pages><issn>0028-3908</issn><eissn>1873-7064</eissn><abstract>Intravenous injection of streptococcal mucopeptide 2mg/kg to rats is followed by a marked temperature elevation and a significant decrease of paradoxical sleep. 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| ispartof | Neuropharmacology, 1973-11, Vol.12 (11), p.1039-1047 |
| issn | 0028-3908 1873-7064 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biogenic Amines - metabolism Body Temperature - drug effects Electrodes, Implanted Electromyography Fever - metabolism Hypothalamus - metabolism Kinetics Male Mesencephalon - metabolism Norepinephrine - metabolism Pargyline - metabolism Peptides - pharmacology Rats Salicylates - pharmacology Serotonin - metabolism Sleep - drug effects Streptococcus Time Factors |
| title | Brain amines in fever and sleep cycle changes caused by streptococcal mucopeptide |
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