Brain amines in fever and sleep cycle changes caused by streptococcal mucopeptide

Brain amines in fever and sleep cycle changes caused by streptococcal mucopeptide

Intravenous injection of streptococcal mucopeptide 2mg/kg to rats is followed by a marked temperature elevation and a significant decrease of paradoxical sleep. The measurement of turnover rates of 5-hydroxytryptamine and noradrenaline in hypothalamus and midbrain, areas involved in temperature and...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neuropharmacology 1973-11, Vol.12 (11), p.1039-1047
Hauptverfasser: Masek, K, Kadlecová, O, Rasková, H
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biogenic Amines - metabolism
Body Temperature - drug effects
Electrodes, Implanted
Electromyography
Fever - metabolism
Hypothalamus - metabolism
Kinetics
Male
Mesencephalon - metabolism
Norepinephrine - metabolism
Pargyline - metabolism
Peptides - pharmacology
Rats
Salicylates - pharmacology
Serotonin - metabolism
Sleep - drug effects
Streptococcus
Time Factors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Intravenous injection of streptococcal mucopeptide 2mg/kg to rats is followed by a marked temperature elevation and a significant decrease of paradoxical sleep. The measurement of turnover rates of 5-hydroxytryptamine and noradrenaline in hypothalamus and midbrain, areas involved in temperature and sleep control, demonstrated a significant increase of 5-hydroxytryptamine turnover in both areas during the fever and paradoxical sleep deprivation. This suggests the activation of 5-hydroxytryptamine neurones and brings further support to the concept relating the indole amines to temperature and sleep regulation.
ISSN:0028-3908
1873-7064
DOI:10.1016/0028-3908(73)90048-8