Blood Level Profile in Man following Chronic Oral Administration of Flurazepam Hydrochloride

The blood level profile of flurazepam and its major metabolites was determined in man following the oral administration of 30mg. daily for 2 weeks. The levels of the intact drug were below the sensitivity limit of the assay (

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1973-12, Vol.62 (12), p.1932-1935
Hauptverfasser:	Kaplan, S.A., de Silva, J.A.F., Jack, M.L., Alexander, K., Strojny, N., Weinfeld, R.E., Puglisi, C.V., Weissman, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Benzodiazepines Benzodiazepines, flurazepam hydrochloride—biotransformation, blood level profile, metabolites Benzodiazepinones - blood Biotransformation Biotransformation-flurazepam hydrochloride after chronic administration Biotransformation—flurazepam hydrochloride after chronic administration, blood level profile including metabolites, half-lives blood level profile blood level profile including metabolites Blood level profile-flurazepam hydrochloride and metabolites after 14 days administration Blood level profile—flurazepam hydrochloride and metabolites after 14 days administration, man Dealkylation Flurazepam - administration & dosage Flurazepam - blood Flurazepam - metabolism Flurazepam hydrochloride and metabolites-blood level profile in man following 14 days administration Flurazepam hydrochloride and metabolites—blood level profile in man following 14 days administration, half-lives flurazepam hydrochloride-biotransformation Half-Life half-lives Humans Hydroxylation Hypnotics and Sedatives - blood Male man metabolites Time Factors
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Beschreibung
Zusammenfassung:	The blood level profile of flurazepam and its major metabolites was determined in man following the oral administration of 30mg. daily for 2 weeks. The levels of the intact drug were below the sensitivity limit of the assay (
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600621205