Glycoprotein biosynthesis in normal and scrapie-affected mouse brain

The rates of incorporation of various radioactively labelled precursors into glycoproteins in the brain has been compared in normal mice and in mice inoculated intracerebrally with the scrapie agent. In the clinical stages of scrapie disease, there is a marked increase in the rates of incorporation...

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Veröffentlicht in:Journal of comparative pathology 1973-01, Vol.83 (2), p.217-224
Hauptverfasser: Hunter, G.D., Millson, G.C.
Format: Artikel
Sprache:eng
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Zusammenfassung:The rates of incorporation of various radioactively labelled precursors into glycoproteins in the brain has been compared in normal mice and in mice inoculated intracerebrally with the scrapie agent. In the clinical stages of scrapie disease, there is a marked increase in the rates of incorporation of labelled l-fucose and d- N-acetylmannosamine into the glycoproteins of scrapie brain. More detailed studies using fucose as a tracer have shown that this increase first becomes detectable in scrapie brain about 10 weeks after inoculation of the agent and increases progressively thereafter until about 18 weeks after inoculation. Studies involving cellular fractionation have indicated that the increased incorporation is not spread uniformly among the different glyco-protein components of the brain.
ISSN:0021-9975
1532-3129
DOI:10.1016/0021-9975(73)90045-5