A COMPARATIVE STUDY OF THE WRITHING RESPONSE INDUCED BY PHENYLQUINONE, BRADYKININ AND ACONITINE FOR THE ASSESSMENT OF ANALGESIC AGENTS

Phenylquinone, bradykinin and aconitine induced writhing syndromes have been compared as to screening suitability for analgesic agents. It was observed that aconitine induced writhing appears more quickly, is more frequent and lasts for a longer period. Drug antagonism studies show that both phenylq...

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Veröffentlicht in:	Japanese journal of pharmacology 1973, Vol.23(5), pp.609-614
Hauptverfasser:	BHALLA, T.N., SINHA, J.N., KOHLI, R.P., BHARGAVA, K.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitum - antagonists & inhibitors Aconitum - pharmacology Analgesics - pharmacology Animals Aspirin - pharmacology Bradykinin - antagonists & inhibitors Bradykinin - pharmacology Codeine - pharmacology Dose-Response Relationship, Drug Mephenesin - pharmacology Mice Morphine - pharmacology Phenacetin - pharmacology Phenylbutazone - pharmacology Quinones - antagonists & inhibitors Quinones - pharmacology Sodium Salicylate - pharmacology Time Factors
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Zusammenfassung:	Phenylquinone, bradykinin and aconitine induced writhing syndromes have been compared as to screening suitability for analgesic agents. It was observed that aconitine induced writhing appears more quickly, is more frequent and lasts for a longer period. Drug antagonism studies show that both phenylquinone and bradykinin induced writhing responses and are antagonised by antipyretics as well as narcotic analgesics, while aconitine induced writhing syndrome, is more selectively antagonised by the antipyretic analgesic agents.
ISSN:	0021-5198 1347-3506
DOI:	10.1254/jjp.23.609