Multifunctional cytotoxic agents from Anacardium occidentale

The effects of anacardic acids and cardols isolated from the cashew nut and apple Anacardium occidentale (Anacardiaceae) on murine B16‐F10 melanoma cells were tested. Although anacardic acids and cardols were found to inhibit tyrosinase, a key enzyme in melanin synthesis, melanogenesis in melanocyte...

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Veröffentlicht in:	Phytotherapy research 2011-01, Vol.25 (1), p.38-45
Hauptverfasser:	Kubo, Isao, Nitoda, Teruhiko, Tocoli, Felismino E., Green, Ivan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	anacardic acids Anacardic Acids - chemistry Anacardic Acids - isolation & purification Anacardic Acids - pharmacology Anacardium - chemistry Anacardium occidentale Animals B16-F10 melanoma cell Biological and medical sciences cardols Cytotoxins - chemistry Cytotoxins - isolation & purification Cytotoxins - pharmacology General pharmacology Medical sciences Melanins - biosynthesis Melanocytes - drug effects Melanoma - pathology Mice Monophenol Monooxygenase - antagonists & inhibitors Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Resorcinols - chemistry Resorcinols - isolation & purification Resorcinols - pharmacology Tumor Cells, Cultured tyrosinase
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Zusammenfassung:	The effects of anacardic acids and cardols isolated from the cashew nut and apple Anacardium occidentale (Anacardiaceae) on murine B16‐F10 melanoma cells were tested. Although anacardic acids and cardols were found to inhibit tyrosinase, a key enzyme in melanin synthesis, melanogenesis in melanocytes was not suppressed in cultured cells but rather enhanced. Both anacardic acids and cardols exhibited moderate cytotoxicity. Copyright © 2010 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.3109