Are glucose readings sufficient to adjust insulin dosage?

insulin therapy is effective predominantly when dosage is frequently adjusted. However, a controversy surrounds the pertinent clinical parameters required to make effective and safe frequent dosage adjustments. We hypothesize that glucose readings are sufficient to adjust insulin dosage provided tha...

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Veröffentlicht in:Diabetes technology & therapeutics 2011-01, Vol.13 (1), p.85-92
Hauptverfasser: Bashan, Eran, Herman, William H, Hodish, Israel
Format: Artikel
Sprache:eng
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Zusammenfassung:insulin therapy is effective predominantly when dosage is frequently adjusted. However, a controversy surrounds the pertinent clinical parameters required to make effective and safe frequent dosage adjustments. We hypothesize that glucose readings are sufficient to adjust insulin dosage provided that dosage is adjusted every 1-4 weeks. to test the hypothesis, we generated several algorithms implemented in software to process glucose readings and recommend insulin dosage adjustments. A post hoc analysis was made on 630 log sheets (2,520 insulin dosage adjustments) from 26 older adults with suboptimally controlled type 2 diabetes. The subjects were followed for a year and treated with intensive insulin therapy that was titrated every 1-4 weeks by a trained study team. More than 88% of subjects attained the treatment goal (hemoglobin A1c
ISSN:1520-9156
1557-8593
DOI:10.1089/dia.2010.0112