The Handy Use of Brown's P2-Ni Catalyst for a Skipped Diyne Deuteration: Application to the Synthesis of a [D4]-Labeled F4t-Neuroprostane

Brown's P2‐Ni does the job: An efficient synthesis of tetradeuterated neuroprostane (see structure) has been accomplished by using an ene–diyne stereoselective deuteration strategy.

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Veröffentlicht in:	Chemistry : a European journal 2010-12, Vol.16 (47), p.13976-13980
Hauptverfasser:	Oger, Camille, Bultel-Poncé, Valérie, Guy, Alexandre, Balas, Laurence, Rossi, Jean-Claude, Durand, Thierry, Galano, Jean-Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Chemistry Deuterium - chemistry Diynes - chemistry Hydrogenation Isotope Labeling isotopic labeling Molecular Structure neuroprostanes Neuroprostanes - chemical synthesis Neuroprostanes - chemistry nickel Nickel - chemistry skipped diynes
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Beschreibung
Zusammenfassung:	Brown's P2‐Ni does the job: An efficient synthesis of tetradeuterated neuroprostane (see structure) has been accomplished by using an ene–diyne stereoselective deuteration strategy.
ISSN:	0947-6539 1521-3765
DOI:	10.1002/chem.201002304