Two novel alkaloids from the South China Sea marine sponge Dysidea sp

Two new alkaloids, dysideanins A ( 1 ) and B ( 2 ), along with two known diketopiperazines, cyclo-(Pro-Leu) ( 3 ) and cyclo-(Pro-Ile) ( 4 ), were isolated from the marine sponge Dysidea sp. The structures were established from NMR and MS analysis. Dysideanin B ( 2 ) exhibited antibacterial activity....

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Veröffentlicht in:	Journal of antibiotics 2010-12, Vol.63 (12), p.699-701
Hauptverfasser:	Ren, Shen, Ma, Wei, Xu, Tunhai, Lin, Xiuping, Yin, Hao, Yang, Bin, Zhou, Xue-Feng, Yang, Xian-Wen, Long, Lijuan, Lee, Kyung Jin, Gao, Qipin, Liu, Yonghong
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/349 631/326/22/1290 639/638/403/936 Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Bacteriology Biomedical and Life Sciences Bioorganic Chemistry China Dysidea - chemistry Imidazoles - chemistry Imidazoles - isolation & purification Imidazoles - pharmacology Life Sciences Medicinal Chemistry Microbial Sensitivity Tests Microbiology Molecular Structure Nuclear Magnetic Resonance, Biomolecular Organic Chemistry original-article Piperidines - chemistry Piperidines - isolation & purification Piperidines - pharmacology Spectrometry, Mass, Electrospray Ionization
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Beschreibung
Zusammenfassung:	Two new alkaloids, dysideanins A ( 1 ) and B ( 2 ), along with two known diketopiperazines, cyclo-(Pro-Leu) ( 3 ) and cyclo-(Pro-Ile) ( 4 ), were isolated from the marine sponge Dysidea sp. The structures were established from NMR and MS analysis. Dysideanin B ( 2 ) exhibited antibacterial activity. The thiomethylated imidazolinium unit as found in dysideanin A is very rarely encountered in nature.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/ja.2010.134