Synthesis of Substituted Cinnamides: Relationship between Anticonvulsant and Monoamine Oxidase Inhibitory Properties

Several esters and hydrazides of substituted cinnamides were synthesized and characterized. Evaluation of their anticonvulsant activity indicated appreciable activity of hydrazides where no correlation could be observed between anticonvulsant activity possessed by these hydrazides and their ability...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1973-12, Vol.62 (12), p.1986-1989
Hauptverfasser:	Parmar, Surendra S., Joshi, P.C., Ali, Basheer, Brumleve, Stanley J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemical synthesis Amides - therapeutic use Animals anticonvulsant activity Anticonvulsant activity-cinnamides of substituted amino acid esters and their hydrazides Anticonvulsant activity—cinnamides of substituted amino acid esters and their hydrazides, relationship to monoamine oxidase inhibitory properties Anticonvulsants - chemical synthesis Anticonvulsants - therapeutic use Cinnamates - chemical synthesis Cinnamates - therapeutic use cinnamides of amino acid esters and their hydrazides-synthesis Cinnamides of substituted amino acid esters and their hydrazides-synthesis Cinnamides of substituted amino acid esters and their hydrazides—synthesis, relationship between anticonvulsant and monoamine oxidase inhibitory properties Manometry Mice Monoamine oxidase inhibitors Monoamine Oxidase Inhibitors - chemical synthesis Monoamine Oxidase Inhibitors - therapeutic use Monoamine oxidase inhibitors, cinnamides of amino acid esters and their hydrazides—synthesis, anticonvulsant activity Myoclonus - prevention & control Pentylenetetrazole - antagonists & inhibitors relationship between anticonvulsant and monoamine oxidase inhibitory properties relationship to monoamine oxidase inhibitory properties Spectrometry, Fluorescence Structure-activity relationships-cinnamides Structure-activity relationships—cinnamides, relationship between anticonvulsant and monoamine oxidase inhibitory properties
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