Comparative Behavior of 16 ECHO Virus Types in Fibroblast-like and Epithelial-Like Human Cell Strains.

Summary The susceptibility ranges of a fibroblast-like and 6 epithelial-like human cell strains to 16 ECHO virus types have been described. All of these ECHO viruses except type 10 multiplied in the fibroblast-like cell strain (Detroit-196 Fb-L). In contrast, an epithelial-like strain (Detroit-196 Ep-L) evolving from the Fb-L strain, as well as 5 additional Ep-L cell strains, either were refractory or had narrow susceptibility ranges. The significance of differences in morphology with respect to virus susceptibility was discussed.