A MODIFICATION OF THE KOELLE TECHNIQUE FOR USE WITH OXIMES

A MODIFICATION OF THE KOELLE TECHNIQUE FOR USE WITH OXIMES

The Koelle histochemical method has been modified to study the effect of oximes on cholinesterase activity at motor endplates. It is possible by lowering the pH to hold the reaction between substrate and oxime to a minimum. With this modified procedure, the inhibitory effect of pyridine-2-aldoxime m...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The journal of histochemistry and cytochemistry 1958-01, Vol.6 (1), p.72-74
Hauptverfasser: BERGNER, A. DOROTHY, O'NEILL, JOHN J
Format: Artikel
Sprache:eng
Schlagworte:
Cholinesterases
Humans
Hydroxylamines - pharmacology
Old Medline
Oximes
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The Koelle histochemical method has been modified to study the effect of oximes on cholinesterase activity at motor endplates. It is possible by lowering the pH to hold the reaction between substrate and oxime to a minimum. With this modified procedure, the inhibitory effect of pyridine-2-aldoxime methiodide and diacetylmonoxime on motor endplate cholinesterase can be demonstrated.
ISSN:0022-1554
1551-5044
DOI:10.1177/6.1.72