Effect of Renal Transplantation on Visual Evoked Potential Abnormalities of Chronic Renal Failure

Abstract Background Cranial neuropathies including optic nerve involvement are well-known complications of chronic renal failure (CRF), but most clinicians often do not follow the progression of these damages during course of CRF or their reversibility after treatment. So, this study evaluates effects of renal transplantation on visual system functions using visual-evoked potentials (VEP). Methods and Materials Forty CRF transplantation candidates and 40 control healthy persons underwent VEP before transplantation. VEP was repeated 3 months later for patients who had successful grafts. Results None of recorded VEP changes were significant in our study, although the absolute number of normal parameters increased after transplantation. In patients who had less than 1 year duration of CRF, more positive changes were observed after transplantation ( p < .05). Conclusion Our study showed the VEP changes were not significant. This may have been due to the delay in transplantation. CRF duration had a significant effect on almost all parameters of VEP which means that the longer duration of CRF lead to a decreased probability of VEP changes to return to normal after transplantation.