Reduction of sebum excretion in man by the antiandrogen, cyproterone acetate

SUMMARY The effect of systemic cyproterone acetate on sebaceous activity was studied in twenty male patients being tested for sexual offences. In every patient the sebum excretion rate (SER) was below the mean SER of untreated normal male subjects of the same age, and the mean SER for the treated male patients was significantly lower than in a control group of normal females. The degree of reduction in SER produced by cyproterone acetate confirms that androgen is a major sebotrophic factor in the human male.