Nonsink Dissolution Rate Equation

An equation was developed which describes the dissolution of monodisperse particles beyond the point where concentrations are small compared to solubility. If it is assumed that a stagnant layer model applies, the thickness of these layers is of the same order of magnitude as calculated via the Hixs...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1973-09, Vol.62 (9), p.1468-1470
Hauptverfasser:	Pothisiri, Pakdee, Thurø Carstensen, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	and p-hydroxybenzoic acid applied to hydrocortisone Benzoates Dihydroxyphenylalanine Dissolution rates Dissolution rates, monodisperse particles—equation developed for nonsink conditions, applied to hydrocortisone, levodopa, and p‐hydroxybenzoic acid Hydrocortisone Kinetics levodopa Mathematics monodisperse particles-equation developed for nonsink conditions monodisperse-nonsink dissolution rate equation developed Particles Particles, monodisperse— nonsink dissolution rate equation developed, applied to hydrocortisone, levodopa, and p-hydroxybenzoic acid Solubility Spectrophotometry, Ultraviolet
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Beschreibung
Zusammenfassung:	An equation was developed which describes the dissolution of monodisperse particles beyond the point where concentrations are small compared to solubility. If it is assumed that a stagnant layer model applies, the thickness of these layers is of the same order of magnitude as calculated via the Hixson-Crowell treatment but dissolution rate constants are 1.5-2 times as large. The application of the equation to dissolution of hydrocortisone, levodopa, and p-hydroxybenzoic acid is shown.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600620916