The sites of action of bumetanide in man

Some pharmacological effects of bumetanide were investigated in 8 healthy volunteers. It was a very potent diuretic, as judged by the fact that, at peak effects during water diuresis, 20% of filtered sodium was excreted in the urine. During water diuresis it reduced free water clearance by approxima...

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Veröffentlicht in:European journal of pharmacology 1973-09, Vol.23 (3), p.283-289
Hauptverfasser: Bourke, E., Asbury, M.J.A., O'Sullivan, S., Gatenby, P.B.B.
Format: Artikel
Sprache:eng
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Zusammenfassung:Some pharmacological effects of bumetanide were investigated in 8 healthy volunteers. It was a very potent diuretic, as judged by the fact that, at peak effects during water diuresis, 20% of filtered sodium was excreted in the urine. During water diuresis it reduced free water clearance by approximately 25% and during hydropoenia it reduced the reabsorption of solute free water to a similar extent, indicating a major site of action on the ascending limb of the loop of Henle. A significant phosphaturia was induced during the period of maximum diuresis suggesting an additional action on the proximal tubule. The excretion of urinary titratable acid and ammonium as well as potassium were increased, indicating that the drug did not have a significant effect on sodium transport in the distal tubule. Glomerular filtration rate was not affected but the drug caused a decrease in the renal clearance of uric acid.
ISSN:0014-2999
1879-0712
DOI:10.1016/0014-2999(73)90096-4