Poly ADP-ribose synthesis and DNA replication in synchronized mouse L-cells

Poly ADP-ribose synthesis and DNA replication in synchronized mouse L-cells

The presence and synthesis of Poly ADP-ribose in vivo has been established in synchronized mouse L-cells. The polymer is synthesized predominantly in two short-lived bursts in the S-phase of the cell cycle. Inhibition of polymer synthesis by nicotinamide (20 mM) during the S-phase inhibits the rate...

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Veröffentlicht in:Biochemical and biophysical research communications 1973-08, Vol.53 (3), p.960-966
Hauptverfasser: Colyer, R.A., Burdette, K.E., Kidwell, W.R.
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine Diphosphate
Animals
Carbon Isotopes
Cell Division
Chromatography, Paper
Chromatography, Thin Layer
DNA Replication
Isotope Labeling
Kinetics
L Cells (Cell Line) - analysis
L Cells (Cell Line) - drug effects
L Cells (Cell Line) - metabolism
Methotrexate - pharmacology
Mice
Mitosis
Molecular Weight
Nucleotidases - metabolism
Polynucleotides - analysis
Polynucleotides - biosynthesis
Polynucleotides - metabolism
Ribose
Species Specificity
Time Factors
Tritium
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Zusammenfassung:The presence and synthesis of Poly ADP-ribose in vivo has been established in synchronized mouse L-cells. The polymer is synthesized predominantly in two short-lived bursts in the S-phase of the cell cycle. Inhibition of polymer synthesis by nicotinamide (20 mM) during the S-phase inhibits the rate of DNA replication subsequent to the time of poly ADP-ribose synthesis.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(73)90185-X