Cell Surface Properties and the Expression of SV40-induced Transformation

Cell Surface Properties and the Expression of SV40-induced Transformation

WHEN SV40 infects the permanent mouse embryo line, Balb 3T3, it can transform the cells' growth properties in a number of ways1. Most commonly, SV40 transformants are selected for their ability to grow to high saturation densities2-4. These standard transformants which can also grow in agar sus...

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Veröffentlicht in:Nature. New biology (London) 1973-09, Vol.245 (142), p.67-69
Hauptverfasser: SMITH, HELENE S, HILLER, ALAN J, KINGSBURY, ELIZABETH W, ROBERTS-DORY, CATHY
Format: Artikel
Sprache:eng
Schlagworte:
Agglutination
Animals
Cell Line
Cell Membrane
Cell Transformation, Neoplastic
Concanavalin A
DNA, Neoplasm - biosynthesis
Fibroblasts
Mice
Microscopy, Electron
Ruthenium
Simian virus 40
Staining and Labeling
Surface Properties
Thymidine - metabolism
Tritium
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Beschreibung
Zusammenfassung:WHEN SV40 infects the permanent mouse embryo line, Balb 3T3, it can transform the cells' growth properties in a number of ways1. Most commonly, SV40 transformants are selected for their ability to grow to high saturation densities2-4. These standard transformants which can also grow in agar suspension5 and in medium lacking serum growth factors (factor-free medium)6 synthesize virus specific tumour (T) and transplantation (TSTA) antigens7,8, and most of them release infectious virions after fusion with permissive cell lines9-11.
ISSN:0090-0028
2058-1092
DOI:10.1038/newbio245067a0