Graft-vs-Host Reaction with an H-2 Mutant

Graft-vs-Host Reaction with an H-2 Mutant

GVHR can be induced across the H-2D locus, presumably uncontaminated by any other genetic differences (Ir); it can also be induced across differences that do not have any histocompatibility effect on skin grafts. This is interpreted as evidence for two types of genes in the H-2 complex, H-genes invo...

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Veröffentlicht in:The Journal of immunology (1950) 1973-09, Vol.111 (3), p.976-979
Hauptverfasser: Klein, J, Egorov, I. K
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Animals, Newborn
Chromosomes
Genotype
Graft vs Host Reaction
Histocompatibility Antigens
Immunogenetics
Injections, Intraperitoneal
Mice
Mutation
Recombination, Genetic
Spleen - cytology
Spleen - immunology
Spleen - transplantation
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Zusammenfassung:GVHR can be induced across the H-2D locus, presumably uncontaminated by any other genetic differences (Ir); it can also be induced across differences that do not have any histocompatibility effect on skin grafts. This is interpreted as evidence for two types of genes in the H-2 complex, H-genes involved in both GVHR and skin graft rejection, and Gvh-genes involved in GVHR but not in skin graft rejection.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.111.3.976