Effect of Angiotonin on the Distribution of Sodium, Potassium and Water in the Rat
STUDIES of ‘Pitressin’ in the bilaterally nephrectomized rat have shown that this extract causes a shift of sodium and water out of the extracellular fluid while potassium moves in 1 . These movements are related to the pressor effect of the extract. Similar shifts are also associated with the press...
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Veröffentlicht in: | Nature (London) 1957-07, Vol.180 (4578), p.194-195 |
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creator | FRIEDMAN, SYDNEY M. FRIEDMAN, CONSTANCE L. NAKASHIMA, MIYOSHI |
description | STUDIES of ‘Pitressin’ in the bilaterally nephrectomized rat have shown that this extract causes a shift of sodium and water out of the extracellular fluid while potassium moves in
1
. These movements are related to the pressor effect of the extract. Similar shifts are also associated with the pressor effects of epinephrine and norepinephrine
2,3
. With all these agents, reverse shifts occur during the decline of the blood pressure back to normal. Based on our interpretation of these and other similar experiments, we have suggested the theory that the regulation of blood pressure depends,
inter alia
, on the sodium transfer systems
4
. We have considered potassium to be of less importance than sodium in this regulation, since shifts of this ion are usually considerably less in total amount. This idea is supported by the present findings with angiotonin (hypertensin) in which sodium shifts were not accompanied by any inverse shift of potassium. |
doi_str_mv | 10.1038/180194a0 |
format | Article |
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1
. These movements are related to the pressor effect of the extract. Similar shifts are also associated with the pressor effects of epinephrine and norepinephrine
2,3
. With all these agents, reverse shifts occur during the decline of the blood pressure back to normal. Based on our interpretation of these and other similar experiments, we have suggested the theory that the regulation of blood pressure depends,
inter alia
, on the sodium transfer systems
4
. We have considered potassium to be of less importance than sodium in this regulation, since shifts of this ion are usually considerably less in total amount. This idea is supported by the present findings with angiotonin (hypertensin) in which sodium shifts were not accompanied by any inverse shift of potassium.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/180194a0</identifier><identifier>PMID: 13451675</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Angiotensins - pharmacology ; Animals ; Anions ; Humanities and Social Sciences ; Ions ; letter ; multidisciplinary ; Old Medline ; Potassium - metabolism ; Rats ; Science ; Science (multidisciplinary) ; Sodium - metabolism ; Water</subject><ispartof>Nature (London), 1957-07, Vol.180 (4578), p.194-195</ispartof><rights>Springer Nature Limited 1957</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-cd4a7971c66d081ea91a31d2565ca2f262541469478c0b679ce16182ae55cea93</citedby><cites>FETCH-LOGICAL-c315t-cd4a7971c66d081ea91a31d2565ca2f262541469478c0b679ce16182ae55cea93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/180194a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/180194a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13451675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FRIEDMAN, SYDNEY M.</creatorcontrib><creatorcontrib>FRIEDMAN, CONSTANCE L.</creatorcontrib><creatorcontrib>NAKASHIMA, MIYOSHI</creatorcontrib><title>Effect of Angiotonin on the Distribution of Sodium, Potassium and Water in the Rat</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>STUDIES of ‘Pitressin’ in the bilaterally nephrectomized rat have shown that this extract causes a shift of sodium and water out of the extracellular fluid while potassium moves in
1
. These movements are related to the pressor effect of the extract. Similar shifts are also associated with the pressor effects of epinephrine and norepinephrine
2,3
. With all these agents, reverse shifts occur during the decline of the blood pressure back to normal. Based on our interpretation of these and other similar experiments, we have suggested the theory that the regulation of blood pressure depends,
inter alia
, on the sodium transfer systems
4
. We have considered potassium to be of less importance than sodium in this regulation, since shifts of this ion are usually considerably less in total amount. This idea is supported by the present findings with angiotonin (hypertensin) in which sodium shifts were not accompanied by any inverse shift of potassium.</description><subject>Angiotensins - pharmacology</subject><subject>Animals</subject><subject>Anions</subject><subject>Humanities and Social Sciences</subject><subject>Ions</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Old Medline</subject><subject>Potassium - metabolism</subject><subject>Rats</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sodium - metabolism</subject><subject>Water</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1957</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpl0FtLwzAYBuAgiptT8BdIrkTBar42p16OOQ8wUKbiZcnSdGZszUzSC_-9kU68EAIJX568kBehUyDXQAp5A5JASRXZQ0OggmeUS7GPhoTkMiOy4AN0FMKKEMJA0EM0gIIy4IIN0XzaNEZH7Bo8bpfWRdfaFrsWxw-Db22I3i66aNMgiRdX225zhZ9dVCGkI1Ztjd9VNB7b_slcxWN00Kh1MCe7fYTe7qavk4ds9nT_OBnPMl0Ai5muqRKlAM15TSQYVYIqoM4ZZ1rlTc5zRoHykgqpyYKLUhvgIHNlGNNJFyN03uduvfvsTIjVxgZt1mvVGteFSkLJ0xIJXvRQexeCN0219Xaj_FcFpPrpr_rtL9GzXWa32Jj6D-4KS-CyByFdtUvjq5XrfJv--T_sG7fldfs</recordid><startdate>19570727</startdate><enddate>19570727</enddate><creator>FRIEDMAN, SYDNEY M.</creator><creator>FRIEDMAN, CONSTANCE L.</creator><creator>NAKASHIMA, MIYOSHI</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19570727</creationdate><title>Effect of Angiotonin on the Distribution of Sodium, Potassium and Water in the Rat</title><author>FRIEDMAN, SYDNEY M. ; FRIEDMAN, CONSTANCE L. ; NAKASHIMA, MIYOSHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-cd4a7971c66d081ea91a31d2565ca2f262541469478c0b679ce16182ae55cea93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1957</creationdate><topic>Angiotensins - pharmacology</topic><topic>Animals</topic><topic>Anions</topic><topic>Humanities and Social Sciences</topic><topic>Ions</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Old Medline</topic><topic>Potassium - metabolism</topic><topic>Rats</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sodium - metabolism</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FRIEDMAN, SYDNEY M.</creatorcontrib><creatorcontrib>FRIEDMAN, CONSTANCE L.</creatorcontrib><creatorcontrib>NAKASHIMA, MIYOSHI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FRIEDMAN, SYDNEY M.</au><au>FRIEDMAN, CONSTANCE L.</au><au>NAKASHIMA, MIYOSHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Angiotonin on the Distribution of Sodium, Potassium and Water in the Rat</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1957-07-27</date><risdate>1957</risdate><volume>180</volume><issue>4578</issue><spage>194</spage><epage>195</epage><pages>194-195</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>STUDIES of ‘Pitressin’ in the bilaterally nephrectomized rat have shown that this extract causes a shift of sodium and water out of the extracellular fluid while potassium moves in
1
. These movements are related to the pressor effect of the extract. Similar shifts are also associated with the pressor effects of epinephrine and norepinephrine
2,3
. With all these agents, reverse shifts occur during the decline of the blood pressure back to normal. Based on our interpretation of these and other similar experiments, we have suggested the theory that the regulation of blood pressure depends,
inter alia
, on the sodium transfer systems
4
. We have considered potassium to be of less importance than sodium in this regulation, since shifts of this ion are usually considerably less in total amount. This idea is supported by the present findings with angiotonin (hypertensin) in which sodium shifts were not accompanied by any inverse shift of potassium.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>13451675</pmid><doi>10.1038/180194a0</doi><tpages>2</tpages></addata></record> |
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subjects | Angiotensins - pharmacology Animals Anions Humanities and Social Sciences Ions letter multidisciplinary Old Medline Potassium - metabolism Rats Science Science (multidisciplinary) Sodium - metabolism Water |
title | Effect of Angiotonin on the Distribution of Sodium, Potassium and Water in the Rat |
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