Metabolism of 5 : 5-Diphenylhydantoin in the Rabbit

Metabolism of 5 : 5-Diphenylhydantoin in the Rabbit

BUTLER 1 has shown that the metabolism of 5 : 5-diphenylhydantoin in man leads to the excretion of what is presumed to be the pure lævorotatory form of 5-( p -hydroxyphenyl)-5-phenylhydantoin, melting point 326–328° (decomp.), [α] 28 D − 16° ( c . 0.4 in ethanol), through hydroxylation in one ring o...

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Veröffentlicht in:Nature (London) 1957-06, Vol.179 (4572), p.1248-1248
Hauptverfasser: GORVIN, J. H., BROWNLEE, G.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Humanities and Social Sciences
Hydantoins - metabolism
letter
multidisciplinary
Old Medline
Phenytoin
Rabbits
Science
Science (multidisciplinary)
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Beschreibung
Zusammenfassung:BUTLER 1 has shown that the metabolism of 5 : 5-diphenylhydantoin in man leads to the excretion of what is presumed to be the pure lævorotatory form of 5-( p -hydroxyphenyl)-5-phenylhydantoin, melting point 326–328° (decomp.), [α] 28 D − 16° ( c . 0.4 in ethanol), through hydroxylation in one ring only. In dogs, however, hydroxylation of either of the two phenyl groups appears to proceed with almost equal facility: the excreted p -hydroxy derivative is slightly dextrorotatory.
ISSN:0028-0836
1476-4687
DOI:10.1038/1791248a0