Chronic effect of ethanol on the metabolism of myocardium

Chronic effect of ethanol on the metabolism of myocardium

Chronic administration of ethanol (2.5 μ/kg for 10 weeks) to rats caused growth retardation, decrease of myocardial glycogen, and a decrease of myocardial homogenate respiration and of glycolytic activity. Heart mitochondrial respiration was slightly lowered but respiratory control decreased signifi...

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Veröffentlicht in:Biochemical pharmacology 1973-07, Vol.22 (14), p.1807-1811
Hauptverfasser: Gvozdják, A., Bada, V., Kruty, F., Niederland, T.R., Gvozdják, J.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Blood Glucose
Body Weight - drug effects
Ethanol - administration & dosage
Ethanol - pharmacology
Glycogen - metabolism
Heart - drug effects
Male
Myocardium - metabolism
Organ Size
Rats
Time Factors
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Zusammenfassung:Chronic administration of ethanol (2.5 μ/kg for 10 weeks) to rats caused growth retardation, decrease of myocardial glycogen, and a decrease of myocardial homogenate respiration and of glycolytic activity. Heart mitochondrial respiration was slightly lowered but respiratory control decreased significantly. Heart weight was unchanged, as was blood glucose. These results are discussed with respect to the possibility of chronic damage to the heart muscle.
ISSN:0006-2952
1873-2968
DOI:10.1016/0006-2952(73)90395-X