Bioavailability of Dicumarol From Different Commercial Tablets in Dogs

The availability of dicumarol from three different commercial tablets was determined by measuring plasma levels in dogs and by an in vitro dissolution rate test. The products showed significant differences in plasma levels, areas under plasma level curves, peak prothrombin time responses, and rates...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1973-07, Vol.62 (7), p.1192-1193
Hauptverfasser:	Akers, M.J., Lach, J.L., Fischer, L.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticoagulants-bioavailability of dicumarol from three different commercial tablets Anticoagulants—bioavailability of dicumarol from three different commercial tablets, dogs Bioavailability-dicumarol from three different commercial tablets Bioavailability—dicumarol from three different commercial tablets, dogs Biopharmaceutics Blood Coagulation - drug effects Dicumarol - administration & dosage Dicumarol - analysis Dicumarol - blood Dicumarol - pharmacology Dicumarol-bioavailability from three different commercial tablets Dicumarol—bioavailability from three different commercial tablets, dogs Dogs Kinetics Prothrombin Time Solubility Spectrophotometry Tablets Time Factors
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Zusammenfassung:	The availability of dicumarol from three different commercial tablets was determined by measuring plasma levels in dogs and by an in vitro dissolution rate test. The products showed significant differences in plasma levels, areas under plasma level curves, peak prothrombin time responses, and rates of dissolution even though they contained the labeled amount of dicumarol.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600620730