Synthesis and MAO Inhibitory Activity of 6-(2-propynyl)-6,7-dihydro-5H-dibenz[c, e]azepine

A propynyl dibenzazepine was synthesized with a view to design a compound that would possess the structural features essential for biological activity present in the antiadrenergic compound azapetine and in the MAO inhibitor pargyline, both of which have been used as antihypertensives. The new compo...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1973-07, Vol.62 (7), p.1204-1205
Hauptverfasser:	Grunder, J. Richard, San, Luke, Kaul, Pushkar N.
Format:	Artikel
Sprache:	eng
Schlagworte:	6-(2-Propynyl)-6 6-(2-Propynyl)-6,7-dihydro-5H-dibenz[c,e]azepine—synthesized and screened as potential MAO inhibitor 7-dihydro-5H-dibenz[c Animals Dibenzazepines - administration & dosage Dibenzazepines - chemical synthesis Dibenzazepines - pharmacology Dibenzazepines-synthesis and screening of 6-(2-propynyl)-6 Dibenzazepines—synthesis and screening of 6-(2-propynyl)-6,7-dihydro-5H-dibenz[c,e]azepine as MAO inhibitor e]azepine e]azepine as MAO inhibitor e]azepine-synthesized and screened as potential MAO inhibitor Iproniazid - pharmacology Liver - enzymology MAO inhibitors MAO inhibitors, potential—synthesis and screening of 6-(2-propynyl)-6,7-dihydro-5H-dibenz[c,e]azepine Methods Mice Monoamine Oxidase Inhibitors - chemical synthesis Pargyline - pharmacology potential-synthesis and screening of 6-(2-propynyl)-6 Time Factors
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Zusammenfassung:	A propynyl dibenzazepine was synthesized with a view to design a compound that would possess the structural features essential for biological activity present in the antiadrenergic compound azapetine and in the MAO inhibitor pargyline, both of which have been used as antihypertensives. The new compound possesses MAO-inhibiting activity weaker than that of pargyline.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600620735