A cytochemical and autoradiographic study of nuclear DNA in mouse Purkinje cells

A cytochemical and autoradiographic study of nuclear DNA in mouse Purkinje cells

A cytophotometric study showed that the content of Feulgen DNA in Purkinje cell nuclei in mouse cerebellum exceeded the diploid level. The DNA content increased postnatally with an acceleration between days 11 and 25. However, no evidence was found for a level of DNA synthesis commensurate with that...

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Veröffentlicht in:Brain research 1973-04, Vol.53 (2), p.273-289
Hauptverfasser: Mareš, VL, Lodin, Z., Šácha, J.
Format: Artikel
Sprache:eng
Schlagworte:
Age Factors
Animals
Autoradiography
Brain - embryology
Cell Nucleus - metabolism
DNA - metabolism
Female
Histocytochemistry
Injections, Intraperitoneal
Mice
Mice, Inbred CBA
Polyploidy
Pregnancy
Purkinje Cells - cytology
Purkinje Cells - metabolism
Thymidine - metabolism
Tritium
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Zusammenfassung:A cytophotometric study showed that the content of Feulgen DNA in Purkinje cell nuclei in mouse cerebellum exceeded the diploid level. The DNA content increased postnatally with an acceleration between days 11 and 25. However, no evidence was found for a level of DNA synthesis commensurate with that expected from the cytophotometric data after the administration of tritiated thymidine during the age period representative for the increase in Feulgen DNA.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(73)90214-X