Alteration of Immunocompetence by Mammary Tumor Virus

Comparison of immunocompetence of 2- to 4-month-old C3HeB/FeJ mice, presumably infected with mammary tumor virus (MTY) by foster-feeding on infected C3H/HeJ mothers, showed that MTV infection was correlated with a depressed ability to mount a hypersensitive reaction to methylated bovine serum albumi...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1973-04, Vol.50 (4), p.1035-1038
Hauptverfasser:	Griswold, D. E., Heppner, G. H., Calabresi, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation Erythrocytes - immunology Female Hemolysin Proteins - biosynthesis Hypersensitivity Male Mammary Tumor Virus, Mouse - immunology Mice Mice, Inbred Strains Serum Albumin, Bovine Sheep - immunology Tumor Virus Infections - immunology
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container_end_page	1038
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container_title	JNCI : Journal of the National Cancer Institute
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creator	Griswold, D. E. Heppner, G. H. Calabresi, P.
description	Comparison of immunocompetence of 2- to 4-month-old C3HeB/FeJ mice, presumably infected with mammary tumor virus (MTY) by foster-feeding on infected C3H/HeJ mothers, showed that MTV infection was correlated with a depressed ability to mount a hypersensitive reaction to methylated bovine serum albumin, with no concomitant depression of humoral antibody production to sheep red blood cells. MTV increased the ability of female mice to make 7S hemolysin. Thus the effect of MTV on immunocompetence is more complex than a simple immunosuppression.
doi_str_mv	10.1093/jnci/50.4.1035
format	Article
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subjects	Animals Antibody Formation Erythrocytes - immunology Female Hemolysin Proteins - biosynthesis Hypersensitivity Male Mammary Tumor Virus, Mouse - immunology Mice Mice, Inbred Strains Serum Albumin, Bovine Sheep - immunology Tumor Virus Infections - immunology
title	Alteration of Immunocompetence by Mammary Tumor Virus
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