Anticonvulsant Activity of Substituted Benzoylpyridines

A series of substituted benzoylpyridines was prepared and evaluated for their ability to prevent convulsions induced by electroshock. Results of regression analysis indicate that electronreleasing substituents enhance anticonvulsant activity in this series. A log P0 of 2.66 was found, which is near...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1973-05, Vol.62 (5), p.847-849
Hauptverfasser:	Dunn, W.J., J., E. Frank, Breen, M.P., Bojanowski, E.M., Cipolle, R.J., Gearien, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants Anticonvulsants - pharmacology Anticonvulsants, potential—synthesis of series of substituted benzoylpyridines, structure-activity correlations Benzoylpyridines Benzoylpyridines, substituted—synthesized as potential anticonvulsants, structure-activity relationships Chemical Phenomena Chemistry, Physical Electroshock Magnetic Resonance Spectroscopy Mathematics Methods Mice Partition coefficients-series of substituted benzoylpyridines Partition coefficients—series of substituted benzoyl-pyridines, synthesized as potential anticonvulsants Partition coefficients—series of substituted benzoylpyridines, synthesized as potential anticonvulsants potential-synthesis of series of substituted benzoylpyridines Pyridines - chemical synthesis Pyridines - pharmacology Regression Analysis Spectrophotometry, Infrared Spectrum Analysis structure-activity correlations Structure-Activity Relationship structure-activity relationships Structure-activity relationships- series of substituted benzoylpyridines, synthesized as potential anticonvulsants Structure-activity relationships-series of substituted benzoylpyridines substituted-synthesized as potential anticonvulsants synthesized as potential anticonvulsants
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Zusammenfassung:	A series of substituted benzoylpyridines was prepared and evaluated for their ability to prevent convulsions induced by electroshock. Results of regression analysis indicate that electronreleasing substituents enhance anticonvulsant activity in this series. A log P0 of 2.66 was found, which is near the average value of 2 found for 16 series of hypnotics.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600620542