Fluoroarterenol: a Fluorine Isostere of Norepinephrine

Fluoroarterenol: a Fluorine Isostere of Norepinephrine

IN an investigation of the enzymatic methylation of norepinephrine, certain of the isosteres of this neurohormone, designed as antagonists of this system, have been synthesized. This communication deals with D , L -3,4-dihydroxy-(α-fluoromethyl)benzylalcohol, fluoroarterenol, its synthesis and biolo...

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Veröffentlicht in:Nature (London) 1957-02, Vol.179 (4553), p.265-266
1. Verfasser: FELLMAN, J. H
Format: Artikel
Sprache:eng
Schlagworte:
Fluorides
Fluorine
Humanities and Social Sciences
letter
multidisciplinary
Norepinephrine - analogs & derivatives
Old Medline
Science
Science (multidisciplinary)
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Zusammenfassung:IN an investigation of the enzymatic methylation of norepinephrine, certain of the isosteres of this neurohormone, designed as antagonists of this system, have been synthesized. This communication deals with D , L -3,4-dihydroxy-(α-fluoromethyl)benzylalcohol, fluoroarterenol, its synthesis and biological properties.
ISSN:0028-0836
1476-4687
DOI:10.1038/179265a0