Erythropoietic response of the neonatal rat to hypertransfusion and erythropoietin (Ep)

Erythropoietic response of the neonatal rat to hypertransfusion and erythropoietin (Ep)

A sustained state of plethora cannot be induced in neonatal rats by intraperitoneal injections of RBC. On the other hand, erythropoiesis is markedly and rapidly suppressed by intra‐cardiac injections of RBC. The data suggest that administration of Ep to such animals results in a two‐fold action: an...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of surgical oncology 1973, Vol.5 (2), p.85-88
Hauptverfasser: Cantor, Linda N., Gordon, Albert S.
Format: Artikel
Sprache:eng
Schlagworte:
Age Factors
Animals
Animals, Newborn - physiology
Blood Transfusion
Child
Erythrocytes
Erythropoiesis - drug effects
Erythropoietin - pharmacology
Female
Hematocrit
Humans
Injections, Intraperitoneal
Methods
Rats - physiology
Reticulocytes - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A sustained state of plethora cannot be induced in neonatal rats by intraperitoneal injections of RBC. On the other hand, erythropoiesis is markedly and rapidly suppressed by intra‐cardiac injections of RBC. The data suggest that administration of Ep to such animals results in a two‐fold action: an early release of reticulocytes followed by a true stimulation of erythropoiesis.
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.2930050203