Proliferation and turnover of glial cells in the forebrain of young adult mice as studied by repeated injections of 3 H-thymidine over a prolonged period of time
The magnitude of glial cell renewal was studied on young adult mice using repeated intraperitoneal injections of 3 H‐thymidine every eight hours over a period of 30 days. Mean labeling indices one hour after the last injection were as follows: Glial cells of the subependymal layer of the lateral ven...
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| Veröffentlicht in: | Journal of comparative neurology (1911) 1973-03, Vol.148 (2), p.211-216 |
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| container_title | Journal of comparative neurology (1911) |
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| creator | Kraus-Ruppert, R Laissue, J Bürki, H Odartchenko, N |
| description | The magnitude of glial cell renewal was studied on young adult mice using repeated intraperitoneal injections of
3
H‐thymidine every eight hours over a period of 30 days. Mean labeling indices one hour after the last injection were as follows: Glial cells of the subependymal layer of the lateral ventricle, 61.5%; oligodendrocytes (various sites), 24 to 36.2%; astrocytes (various sites), 14.3 to 30.8%, and satellites in the cerebral cortex, 32.7%. Since DNA synthesis time of the proliferating, immature glial cells is unknown and may be shorter than the time interval of eight hours chosen for repeated injections of
3
H‐thymidine, these results are interpreted as representing minimum values for turnover, during 30 days, of the various cell types in different areas of the forebrain. The significance of a marked proliferative activity of the glial cells as related to differentiation and possible migration of subependymal cells, is discussed. |
| doi_str_mv | 10.1002/cne.901480206 |
| format | Article |
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3
H‐thymidine every eight hours over a period of 30 days. Mean labeling indices one hour after the last injection were as follows: Glial cells of the subependymal layer of the lateral ventricle, 61.5%; oligodendrocytes (various sites), 24 to 36.2%; astrocytes (various sites), 14.3 to 30.8%, and satellites in the cerebral cortex, 32.7%. Since DNA synthesis time of the proliferating, immature glial cells is unknown and may be shorter than the time interval of eight hours chosen for repeated injections of
3
H‐thymidine, these results are interpreted as representing minimum values for turnover, during 30 days, of the various cell types in different areas of the forebrain. The significance of a marked proliferative activity of the glial cells as related to differentiation and possible migration of subependymal cells, is discussed.</description><identifier>ISSN: 0021-9967</identifier><identifier>EISSN: 1096-9861</identifier><identifier>DOI: 10.1002/cne.901480206</identifier><identifier>PMID: 4700508</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Autoradiography ; Brain - growth & development ; Brain - metabolism ; Cell Differentiation ; Cell Movement ; Cerebral Cortex - cytology ; Cerebral Cortex - metabolism ; Cerebral Ventricles - cytology ; Cerebral Ventricles - metabolism ; DNA - biosynthesis ; Mice ; Neuroglia ; Thymidine - metabolism ; Tritium</subject><ispartof>Journal of comparative neurology (1911), 1973-03, Vol.148 (2), p.211-216</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1358-2fd2a7ee5b3649c18954ef20e2a5c94b37f3248c8ad7687117d15e8de39a02893</citedby><cites>FETCH-LOGICAL-c1358-2fd2a7ee5b3649c18954ef20e2a5c94b37f3248c8ad7687117d15e8de39a02893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4700508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kraus-Ruppert, R</creatorcontrib><creatorcontrib>Laissue, J</creatorcontrib><creatorcontrib>Bürki, H</creatorcontrib><creatorcontrib>Odartchenko, N</creatorcontrib><title>Proliferation and turnover of glial cells in the forebrain of young adult mice as studied by repeated injections of 3 H-thymidine over a prolonged period of time</title><title>Journal of comparative neurology (1911)</title><addtitle>J Comp Neurol</addtitle><description>The magnitude of glial cell renewal was studied on young adult mice using repeated intraperitoneal injections of
3
H‐thymidine every eight hours over a period of 30 days. Mean labeling indices one hour after the last injection were as follows: Glial cells of the subependymal layer of the lateral ventricle, 61.5%; oligodendrocytes (various sites), 24 to 36.2%; astrocytes (various sites), 14.3 to 30.8%, and satellites in the cerebral cortex, 32.7%. Since DNA synthesis time of the proliferating, immature glial cells is unknown and may be shorter than the time interval of eight hours chosen for repeated injections of
3
H‐thymidine, these results are interpreted as representing minimum values for turnover, during 30 days, of the various cell types in different areas of the forebrain. The significance of a marked proliferative activity of the glial cells as related to differentiation and possible migration of subependymal cells, is discussed.</description><subject>Animals</subject><subject>Autoradiography</subject><subject>Brain - growth & development</subject><subject>Brain - metabolism</subject><subject>Cell Differentiation</subject><subject>Cell Movement</subject><subject>Cerebral Cortex - cytology</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cerebral Ventricles - cytology</subject><subject>Cerebral Ventricles - metabolism</subject><subject>DNA - biosynthesis</subject><subject>Mice</subject><subject>Neuroglia</subject><subject>Thymidine - metabolism</subject><subject>Tritium</subject><issn>0021-9967</issn><issn>1096-9861</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU1v2zAMhoViQ5qlPfZYgKfdnEqWP6TjEKzLgADdYTsbskQnKmwpk-QB-Tn7p5PXoCeS4MOXJF5CHhjdMkrLJ-1wKymrBC1pc0PWjMqmkKJhH8g691khZdPekk8xvlJKpeRiRVZVS2lNxZr8_RH8aAcMKlnvQDkDaQ7O_8EAfoDjaNUIGscxgnWQTgiDD9gHlavcv_jZHUGZeUwwWY2gIsQ0G4sG-gsEPKNKObfuFfWyIS5THPZFOl0ma6xD-L9LwTkf4t0xw2cM1psFTHbCO_JxUGPE-2vckF_PX3_u9sXh5dv33ZdDoRmvRVEOplQtYt3zppKaCVlXOJQUS1VrWfW8HXhZCS2UaRvRMtYaVqMwyKWipZB8Qz6_6eZDfs8YUzfZuHyuHPo5diJLNqwWGSzeQB18jAGH7hzspMKlY7RbLOmyJd27JZl_vArP_YTmnb56wP8BmLCJMQ</recordid><startdate>19730315</startdate><enddate>19730315</enddate><creator>Kraus-Ruppert, R</creator><creator>Laissue, J</creator><creator>Bürki, H</creator><creator>Odartchenko, N</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19730315</creationdate><title>Proliferation and turnover of glial cells in the forebrain of young adult mice as studied by repeated injections of 3 H-thymidine over a prolonged period of time</title><author>Kraus-Ruppert, R ; Laissue, J ; Bürki, H ; Odartchenko, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1358-2fd2a7ee5b3649c18954ef20e2a5c94b37f3248c8ad7687117d15e8de39a02893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Autoradiography</topic><topic>Brain - growth & development</topic><topic>Brain - metabolism</topic><topic>Cell Differentiation</topic><topic>Cell Movement</topic><topic>Cerebral Cortex - cytology</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cerebral Ventricles - cytology</topic><topic>Cerebral Ventricles - metabolism</topic><topic>DNA - biosynthesis</topic><topic>Mice</topic><topic>Neuroglia</topic><topic>Thymidine - metabolism</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kraus-Ruppert, R</creatorcontrib><creatorcontrib>Laissue, J</creatorcontrib><creatorcontrib>Bürki, H</creatorcontrib><creatorcontrib>Odartchenko, N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of comparative neurology (1911)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kraus-Ruppert, R</au><au>Laissue, J</au><au>Bürki, H</au><au>Odartchenko, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proliferation and turnover of glial cells in the forebrain of young adult mice as studied by repeated injections of 3 H-thymidine over a prolonged period of time</atitle><jtitle>Journal of comparative neurology (1911)</jtitle><addtitle>J Comp Neurol</addtitle><date>1973-03-15</date><risdate>1973</risdate><volume>148</volume><issue>2</issue><spage>211</spage><epage>216</epage><pages>211-216</pages><issn>0021-9967</issn><eissn>1096-9861</eissn><abstract>The magnitude of glial cell renewal was studied on young adult mice using repeated intraperitoneal injections of
3
H‐thymidine every eight hours over a period of 30 days. Mean labeling indices one hour after the last injection were as follows: Glial cells of the subependymal layer of the lateral ventricle, 61.5%; oligodendrocytes (various sites), 24 to 36.2%; astrocytes (various sites), 14.3 to 30.8%, and satellites in the cerebral cortex, 32.7%. Since DNA synthesis time of the proliferating, immature glial cells is unknown and may be shorter than the time interval of eight hours chosen for repeated injections of
3
H‐thymidine, these results are interpreted as representing minimum values for turnover, during 30 days, of the various cell types in different areas of the forebrain. The significance of a marked proliferative activity of the glial cells as related to differentiation and possible migration of subependymal cells, is discussed.</abstract><cop>United States</cop><pmid>4700508</pmid><doi>10.1002/cne.901480206</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of comparative neurology (1911), 1973-03, Vol.148 (2), p.211-216 |
| issn | 0021-9967 1096-9861 |
| language | eng |
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| source | Access via Wiley Online Library; MEDLINE |
| subjects | Animals Autoradiography Brain - growth & development Brain - metabolism Cell Differentiation Cell Movement Cerebral Cortex - cytology Cerebral Cortex - metabolism Cerebral Ventricles - cytology Cerebral Ventricles - metabolism DNA - biosynthesis Mice Neuroglia Thymidine - metabolism Tritium |
| title | Proliferation and turnover of glial cells in the forebrain of young adult mice as studied by repeated injections of 3 H-thymidine over a prolonged period of time |
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