Proliferation and turnover of glial cells in the forebrain of young adult mice as studied by repeated injections of 3 H-thymidine over a prolonged period of time
The magnitude of glial cell renewal was studied on young adult mice using repeated intraperitoneal injections of 3 H‐thymidine every eight hours over a period of 30 days. Mean labeling indices one hour after the last injection were as follows: Glial cells of the subependymal layer of the lateral ven...
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Veröffentlicht in: | Journal of comparative neurology (1911) 1973-03, Vol.148 (2), p.211-216 |
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Sprache: | eng |
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Zusammenfassung: | The magnitude of glial cell renewal was studied on young adult mice using repeated intraperitoneal injections of
3
H‐thymidine every eight hours over a period of 30 days. Mean labeling indices one hour after the last injection were as follows: Glial cells of the subependymal layer of the lateral ventricle, 61.5%; oligodendrocytes (various sites), 24 to 36.2%; astrocytes (various sites), 14.3 to 30.8%, and satellites in the cerebral cortex, 32.7%. Since DNA synthesis time of the proliferating, immature glial cells is unknown and may be shorter than the time interval of eight hours chosen for repeated injections of
3
H‐thymidine, these results are interpreted as representing minimum values for turnover, during 30 days, of the various cell types in different areas of the forebrain. The significance of a marked proliferative activity of the glial cells as related to differentiation and possible migration of subependymal cells, is discussed. |
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ISSN: | 0021-9967 1096-9861 |
DOI: | 10.1002/cne.901480206 |