Inflammation‐related effects of adjuvant influenza A vaccination on platelet activation and cardiac autonomic function

.  Lanza GA, Barone L, Scalone G, Pitocco D, Sgueglia GA, Mollo R, Nerla R, Zaccardi F, Ghirlanda G, Crea F (Istituto di Cardiologia; and Università Cattolica del Sacro Cuore, Roma; Italy). Inflammation‐related effects of adjuvant influenza A vaccination on platelet activation and cardiac autonomic...

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Veröffentlicht in:Journal of internal medicine 2011-01, Vol.269 (1), p.118-125
Hauptverfasser: Lanza, Gaetano A., Barone, Lucy, Scalone, Giancarla, Pitocco, Dario, Sgueglia, Gregory A., Mollo, Roberto, Nerla, Roberto, Zaccardi, Francesco, Ghirlanda, Giovanni, Crea, Filippo
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Sprache:eng
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Zusammenfassung:.  Lanza GA, Barone L, Scalone G, Pitocco D, Sgueglia GA, Mollo R, Nerla R, Zaccardi F, Ghirlanda G, Crea F (Istituto di Cardiologia; and Università Cattolica del Sacro Cuore, Roma; Italy). Inflammation‐related effects of adjuvant influenza A vaccination on platelet activation and cardiac autonomic function. J Intern Med 2010; 269: 118–125. Background.  Inflammation, platelet reactivity and cardiac autonomic dysfunction increase the risk of cardiovascular events, but the relationships between these prognostic markers are poorly defined. In this study, we investigated the effect of an inflammatory stimulus (influenza A vaccine) on platelet activation and cardiac autonomic function. Methods.  We measured serum C‐reactive protein (CRP) and interleukin‐6 levels, monocyte–platelet aggregates (MPAs) and monocyte/platelet receptor expression before and after adjuvant influenza A vaccination in 28 patients with type II diabetes (mean age 62.1 ± 8 years, 18 men). Twenty‐four‐hour Holter electrocardiogram was recorded 24 h before and  after vaccination; heart rate variability (HRV) was assessed as a measure of cardiac autonomic function. Results.  Inflammatory cytokines, MPA formation and monocyte/platelet receptor expression increased after vaccination. CRP was 2.6 ± 2.8 and 7.1 ± 5.7 mg L−1 48 h before and  after vaccination, respectively (P 
ISSN:0954-6820
1365-2796
DOI:10.1111/j.1365-2796.2010.02285.x