Effect of Anoceptin on Detoxifying Function of the Liver
The absence of negative effects of anoceptin on the liver tissue and detoxifying function was proven experimentally in vitro and in vivo. It was proven for the fi rst time that comenic acid (anoceptin active substance) in concentrations of 10-4-10-12 does not modulate the growth of liver explants fr...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2010-12, Vol.150 (1), p.53-54 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Kipenko, A. V Penniyaynen, V. A Lopatina, E. V Tsyrlin, V. A Lobov, G. I Krylov, B. V |
| description | The absence of negative effects of anoceptin on the liver tissue and detoxifying function was proven experimentally in vitro and in vivo. It was proven for the fi rst time that comenic acid (anoceptin active substance) in concentrations of 10-4-10-12 does not modulate the growth of liver explants from 10-12-day chicken embryos. The effect of anoceptin on the detoxifying function of the liver was studied on Wistar rats under conditions of hexenal-induced sleep. The drug was injected into the caudal vein for 90 days in a daily dose of 5, 100, or 300 mg/kg. The duration of hexenal-induced sleep was evaluated before and on days 30 and 90 of the study. Anoceptin did not modify the duration of hexenal-induced sleep and the status and detoxifying function of the liver. |
| doi_str_mv | 10.1007/s10517-010-1066-1 |
| format | Article |
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Anoceptin did not modify the duration of hexenal-induced sleep and the status and detoxifying function of the liver.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-010-1066-1</identifier><identifier>PMID: 21161050</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Animals ; anoceptin ; Biomedical and Life Sciences ; Biomedicine ; Carboxylic Acids - pharmacology ; Cell Biology ; Chick Embryo ; Chickens ; comenic acid ; Dose-Response Relationship, Drug ; Female ; hexenal sleep ; Injections, Intravenous ; Internal Medicine ; Laboratory Medicine ; liver ; Liver - enzymology ; Liver - metabolism ; Male ; Microsomes, Liver - drug effects ; Microsomes, Liver - enzymology ; Pathology ; Pyrones - pharmacology ; Rats ; Rats, Wistar ; Sleep</subject><ispartof>Bulletin of experimental biology and medicine, 2010-12, Vol.150 (1), p.53-54</ispartof><rights>Springer Science+Business Media, Inc. 2010</rights><rights>COPYRIGHT 2010 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-010-1066-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-010-1066-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21161050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kipenko, A. 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The drug was injected into the caudal vein for 90 days in a daily dose of 5, 100, or 300 mg/kg. The duration of hexenal-induced sleep was evaluated before and on days 30 and 90 of the study. Anoceptin did not modify the duration of hexenal-induced sleep and the status and detoxifying function of the liver.</description><subject>Animals</subject><subject>anoceptin</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Carboxylic Acids - pharmacology</subject><subject>Cell Biology</subject><subject>Chick Embryo</subject><subject>Chickens</subject><subject>comenic acid</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>hexenal sleep</subject><subject>Injections, Intravenous</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>liver</subject><subject>Liver - enzymology</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Microsomes, Liver - drug effects</subject><subject>Microsomes, Liver - enzymology</subject><subject>Pathology</subject><subject>Pyrones - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sleep</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kVtv1DAQhS0EokvhB_ACEZXgKWXGtziPq14AaSUeoM-Wm9i7rrL2YieI_nscUi5FCPnBmvF3jmZ8CHmOcIoAzduMILCpAaFGkLLGB2SFomG1ohQfkhUUqOZKqSPyJOebuQSJj8kRRZRFCyuiLpyz3VhFV61D7Oxh9KGKoTq3Y_zm3a0P2-pyCt3oS7NA485WG__VpqfkkTNDts_u7mNydXnx-ex9vfn47sPZelN3nPOxFtaAcn2PTOE1qFY0vRPCSUcNa0UvKHeN60CyVjlmXUcpN5YDa3tqZAOMHZM3i-8hxS-TzaPe-9zZYTDBxilrhUpyQE4L-eov8iZOKZThCiSo4q1oC3SyQFszWO2Di2My3Wyp14xRKRrRYqFO_0GV09u972Kwzpf-PcHrPwQ7a4Zxl-Mwzd-W74O4gF2KOSfr9CH5vUm3GkHPoeolVA0_ain1rHlxt9h0vbf9L8XPFAtAFyCXp7C16ffm_3N9uYicidpsk8_66hMFZIAtNoy37DtTFLBO</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Kipenko, A. 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V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-5ea08fdd1381b08957df55f6f2a395d524f7fc06398f3efc224ae4039d2a67033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>anoceptin</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Carboxylic Acids - pharmacology</topic><topic>Cell Biology</topic><topic>Chick Embryo</topic><topic>Chickens</topic><topic>comenic acid</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>hexenal sleep</topic><topic>Injections, Intravenous</topic><topic>Internal Medicine</topic><topic>Laboratory Medicine</topic><topic>liver</topic><topic>Liver - enzymology</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Microsomes, Liver - drug effects</topic><topic>Microsomes, Liver - enzymology</topic><topic>Pathology</topic><topic>Pyrones - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sleep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kipenko, A. 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The effect of anoceptin on the detoxifying function of the liver was studied on Wistar rats under conditions of hexenal-induced sleep. The drug was injected into the caudal vein for 90 days in a daily dose of 5, 100, or 300 mg/kg. The duration of hexenal-induced sleep was evaluated before and on days 30 and 90 of the study. Anoceptin did not modify the duration of hexenal-induced sleep and the status and detoxifying function of the liver.</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><pmid>21161050</pmid><doi>10.1007/s10517-010-1066-1</doi><tpages>2</tpages></addata></record> |
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| ispartof | Bulletin of experimental biology and medicine, 2010-12, Vol.150 (1), p.53-54 |
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| subjects | Animals anoceptin Biomedical and Life Sciences Biomedicine Carboxylic Acids - pharmacology Cell Biology Chick Embryo Chickens comenic acid Dose-Response Relationship, Drug Female hexenal sleep Injections, Intravenous Internal Medicine Laboratory Medicine liver Liver - enzymology Liver - metabolism Male Microsomes, Liver - drug effects Microsomes, Liver - enzymology Pathology Pyrones - pharmacology Rats Rats, Wistar Sleep |
| title | Effect of Anoceptin on Detoxifying Function of the Liver |
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