Effect of Anoceptin on Detoxifying Function of the Liver

The absence of negative effects of anoceptin on the liver tissue and detoxifying function was proven experimentally in vitro and in vivo. It was proven for the fi rst time that comenic acid (anoceptin active substance) in concentrations of 10-4-10-12 does not modulate the growth of liver explants from 10-12-day chicken embryos. The effect of anoceptin on the detoxifying function of the liver was studied on Wistar rats under conditions of hexenal-induced sleep. The drug was injected into the caudal vein for 90 days in a daily dose of 5, 100, or 300 mg/kg. The duration of hexenal-induced sleep was evaluated before and on days 30 and 90 of the study. Anoceptin did not modify the duration of hexenal-induced sleep and the status and detoxifying function of the liver.