Determination of Liothyronine and Thyroxine in Dried Thyroid by GLC

The analysis reported here was successful in the quantitative determination of liothyronine and thyroxine in driedthyroid. Three basic steps were employed: (a) hydrolysis of the dried thyroid to release the iodoamino acids from their protein linkage, (b) separation of liothyronine and thyroxine from...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1973-02, Vol.62 (2), p.274-277
Hauptverfasser:	Bilous, Roman, Windheuser, John J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatography, Gas dried-separation GLC analysis GLC analysis in dried thyroid GLC—analysis, liothyronine and thyroxine in dried thyroid Hydrolysis Light liothyronine and thyroxine liothyronine and thyroxine in dried thyroid Liothyronine and thyroxine-separation Liothyronine and thyroxine—separation, GLC analysis in dried thyroid Mathematics Methods Solutions Solvents Swine Thyroid Thyroid Gland - analysis Thyroid, dried—separation, GLC analysis, liothyronine and thyroxine Thyroxine - analysis Thyroxine - isolation & purification Thyroxine and liothyronine-separation Thyroxine and liothyronine—separation, GLC analysis in dried thyroid Triiodothyronine - analysis Triiodothyronine - isolation & purification
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Beschreibung
Zusammenfassung:	The analysis reported here was successful in the quantitative determination of liothyronine and thyroxine in driedthyroid. Three basic steps were employed: (a) hydrolysis of the dried thyroid to release the iodoamino acids from their protein linkage, (b) separation of liothyronine and thyroxine from the interfering substances by extraction and column chromatography, and (c) detection and quantitation by GLC.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600620220