Facile Preparation of a Hybrid Nanoprobe for Triple-Modality Optical/PET/MR Imaging

Facile Preparation of a Hybrid Nanoprobe for Triple-Modality Optical/PET/MR Imaging

A facile method of preparing triple‐modality, optical–nuclear–magnetic imaging probes using radiolabeled superparamagnetic nanoparticles is developed. Cerenkov luminescence imaging based on radionuclides showed great potential as a new optical imaging modality. The complementary nature of the optica...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2010-12, Vol.6 (24), p.2863-2868
Hauptverfasser: Park, Jeong Chan, Yu, Mi Kyung, An, Gwang Il, Park, Se-Il, Oh, Jungmin, Kim, Hong Joo, Kim, Joo-Hyun, Wang, Eun Kyung, Hong, Il-Hwa, Ha, Yeong Su, Choi, Tae Hyun, Jeong, Kyu-Shik, Chang, Yongmin, Welch, Michael J., Jon, Sangyong, Yoo, Jeongsoo
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
hybrid materials
imaging agents
Magnetic Resonance Imaging - methods
multimodality imaging
nanoparticles
Nanotechnology - instrumentation
Nanotechnology - methods
Optical Devices
Positron-Emission Tomography - methods
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Zusammenfassung:A facile method of preparing triple‐modality, optical–nuclear–magnetic imaging probes using radiolabeled superparamagnetic nanoparticles is developed. Cerenkov luminescence imaging based on radionuclides showed great potential as a new optical imaging modality. The complementary nature of the optical/PET/MR hybrid nanoprobes facilitated non‐invasive differentiation between tumor‐metastasized sentinel lymph nodes (SLNs) and tumor‐free SLNs.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201001418