Cobalt- and Manganese-Catalyzed Direct Amination of Azoles under Mild Reaction Conditions and the Mechanistic Details

A bonding moment: A new cobalt‐ or manganese‐catalyzed amination of azoles has been developed using peroxide and an acid additive to couple various types of azoles with ammonia, and primary or secondary amines (see scheme). The catalyst loadings are low, the optimal reaction conditions are mild, and the substrate scope is broad. The product azoles are an important pharmacophore of high biological activity.