A two step route to indoles from haloarenes--a versatile variation on the Fischer indole synthesis

A two step route to indoles from haloarenes--a versatile variation on the Fischer indole synthesis

In a new variation on the Fischer indole synthesis, readily available haloarenes are converted into a wide range of indoles in just two steps by halogen-magnesium exchange, quenching with di-tert-butyl azodicarboxylate, followed by reaction with ketones under acidic conditions.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2011-01, Vol.47 (2), p.788-790
Hauptverfasser: Inman, Martyn, Moody, Christopher J
Format: Artikel
Sprache:eng
Schlagworte:
Halogens - chemistry
Indoles
Indoles - chemical synthesis
Indoles - chemistry
Ketones
Ketones - chemistry
Magnesium - chemistry
Quenching
Synthesis
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Beschreibung
Zusammenfassung:In a new variation on the Fischer indole synthesis, readily available haloarenes are converted into a wide range of indoles in just two steps by halogen-magnesium exchange, quenching with di-tert-butyl azodicarboxylate, followed by reaction with ketones under acidic conditions.
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc04306k