Production of Migration Inhibitory Factor by Non-Dividing Lymphocytes

Production of Migration Inhibitory Factor by Non-Dividing Lymphocytes

Lymphocyte proliferation in response to antigen was essentially eliminated by treatment with 5-bromo-2-deoxyuridine and light. The remaining lymphocytes were restimulated with the same antigen and the production of migration inhibitory factor (MIF) was determined. Under these conditions, MIF activit...

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Veröffentlicht in:The Journal of immunology (1950) 1973-03, Vol.110 (3), p.674-678
1. Verfasser: Rocklin, R. E
Format: Artikel
Sprache:eng
Schlagworte:
Cell Division
Cell Migration Inhibition
Cells, Cultured
Deoxyuridine - pharmacology
Humans
Light
Lymphocytes - immunology
Streptodornase and Streptokinase
Thymidine - metabolism
Tritium
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Zusammenfassung:Lymphocyte proliferation in response to antigen was essentially eliminated by treatment with 5-bromo-2-deoxyuridine and light. The remaining lymphocytes were restimulated with the same antigen and the production of migration inhibitory factor (MIF) was determined. Under these conditions, MIF activity was still present. In addition, the absence of dividing cells did not appear to diminish significantly the amount of MIF produced.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.110.3.674