A study of C-reactive protein in the serum of patients with congestive heart failure

Forty patients manifesting congestive heart failure have been studied with serial serum determinations for C-reactive protein. This abnormal protein was found in thirty instances. No demonstrable difference in age, sex, or race were noted between the two groups. In those patients in whom C-reactive protein was present, the congestive heart failure appeared to be more severe. Fever, elevated erythrocyte sedimentation rate, and pulmonary abnormalities were more common in the group in which C-reactive protein occurred. In approximately one-half of the group in which C-reactive protein was found, the protein was initially present but disappeared after one to two weeks of treatment. In six patients, the C-reactive protein persisted in the blood throughout the hospital course. Single determinations of C-reactive protein were made in the blood of ten patients in whom congestive heart failure was stationary. In no instance was C-reactive protein present. The presence of C-reactive protein in the blood of patients with congestive heart failure limits the application of C-reactive protein determinations as a measure of rheumatic activity in acute rheumatic fever and in chronic rheumatic heart disease and as a measure of necrosis in acute myocardial infarction. Quaranta patientes con manifestationes de congestive disfallimento cardiac esseva subjicite a determinationes serial del proteina C-reactive in le sero. Iste anormal pretiena esseva trovate in trenta casos. Nulle correlation esseva demonstrabile inter le presentia de proteina C-reactive e sexo, etate, o racia del patiente. In le presentia de proteina C-reactive le congestive disfallimento cardiac pareva esser plus sever. Febre, accelerate sedimentation erythrocytic, e anormalitates pulmonar esseva plus commun in le gruppo del patientes in qui proteina C-reactive esseva presente. In circa un medietate del patientes in qui proteina C-reactive esseva trovate, le proteina esseva presente initialmente sed dispareva post un a duo septimanas del tractamento. In sex patientes le proteina C-reactive persisteva a transverso le integre curso hospitalari. Determinationes individual de proteina C-reactive esseva executate in le sanguine de dece patientes in qui le congestive disfallimento cardiac esseva stationari. Proteina C-reactive esseva absente in omne iste casos. Le presentia de proteina C-reactive in le sanguine de patientes con congestive disfallimento cardiac reduce le applicabilitate de determinationes de protein