Hematogenous Pyelonephritis in Rats. II. Production of Chronic Pyelonephritis by Escherichia coli.

Summary and Conclusions 1) Chronic bilateral pyelonephritis without manifest hydronephrosis was produced experimentally in the albino rat by a simple non-surgical technique. This experimental disease provides a model for study of human pyelonephritis. 2) Renal inflammation tended to persist after infection had disappeared. 3) Vascular disesae and hypertension did not develop; however, the lesions were of insufficient severity to produce azotemia.