Cholesterol Hydroperoxide Formation in Red Cell Membranes and Photohemolysis in Erythropoietic Protoporphyria
3β-Hydroxy-5α-hydroperoxy-$\Delta ^{6}$-cholestene is produced in protoporphyrin-containing red blood cell ghosts irradiated with approximately 400-nanometer light in the presence of oxygen. Incorporation of this cholesterol photooxidation product into normal red blood cells leads to increased osmot...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1973-03, Vol.179 (4078), p.1131-1133 |
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| container_end_page | 1133 |
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| container_issue | 4078 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 179 |
| creator | Lamola, A. A. Yamane, T. Trozzolo, A. M. |
| description | 3β-Hydroxy-5α-hydroperoxy-$\Delta ^{6}$-cholestene is produced in protoporphyrin-containing red blood cell ghosts irradiated with approximately 400-nanometer light in the presence of oxygen. Incorporation of this cholesterol photooxidation product into normal red blood cells leads to increased osmotic fragility and eventual hemolysis. These results may be relevant to photohemolysis associated with erythropoietic protoporphyria. |
| doi_str_mv | 10.1126/science.179.4078.1131 |
| format | Article |
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A. ; Yamane, T. ; Trozzolo, A. M.</creator><creatorcontrib>Lamola, A. A. ; Yamane, T. ; Trozzolo, A. M.</creatorcontrib><description>3β-Hydroxy-5α-hydroperoxy-$\Delta ^{6}$-cholestene is produced in protoporphyrin-containing red blood cell ghosts irradiated with approximately 400-nanometer light in the presence of oxygen. Incorporation of this cholesterol photooxidation product into normal red blood cells leads to increased osmotic fragility and eventual hemolysis. These results may be relevant to photohemolysis associated with erythropoietic protoporphyria.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.179.4078.1131</identifier><identifier>PMID: 4689217</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Carbon Isotopes ; Cell Membrane - metabolism ; Cholesterol - metabolism ; Cholesterol - pharmacology ; Cholesterols ; Chromosomes ; Convulsants ; Enzymes ; Erythrocytes - cytology ; Erythrocytes - metabolism ; Hemolysis ; Humans ; Hybridity ; Liposomes ; Osmotic fragility ; Osmotic Fragility - drug effects ; P branes ; Peroxides - biosynthesis ; Peroxides - metabolism ; Peroxides - pharmacology ; Photochemistry ; Photolysis ; Porphyrias - blood ; Porphyrias - metabolism ; Protoporphyrins</subject><ispartof>Science (American Association for the Advancement of Science), 1973-03, Vol.179 (4078), p.1131-1133</ispartof><rights>Copyright 1973 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-fba34c3b3c4ad4000651d21df1154f4166dd7b7b95cc620f656087babc4f174c3</citedby><cites>FETCH-LOGICAL-c356t-fba34c3b3c4ad4000651d21df1154f4166dd7b7b95cc620f656087babc4f174c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1734993$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1734993$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4689217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lamola, A. A.</creatorcontrib><creatorcontrib>Yamane, T.</creatorcontrib><creatorcontrib>Trozzolo, A. M.</creatorcontrib><title>Cholesterol Hydroperoxide Formation in Red Cell Membranes and Photohemolysis in Erythropoietic Protoporphyria</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>3β-Hydroxy-5α-hydroperoxy-$\Delta ^{6}$-cholestene is produced in protoporphyrin-containing red blood cell ghosts irradiated with approximately 400-nanometer light in the presence of oxygen. Incorporation of this cholesterol photooxidation product into normal red blood cells leads to increased osmotic fragility and eventual hemolysis. These results may be relevant to photohemolysis associated with erythropoietic protoporphyria.</description><subject>Carbon Isotopes</subject><subject>Cell Membrane - metabolism</subject><subject>Cholesterol - metabolism</subject><subject>Cholesterol - pharmacology</subject><subject>Cholesterols</subject><subject>Chromosomes</subject><subject>Convulsants</subject><subject>Enzymes</subject><subject>Erythrocytes - cytology</subject><subject>Erythrocytes - metabolism</subject><subject>Hemolysis</subject><subject>Humans</subject><subject>Hybridity</subject><subject>Liposomes</subject><subject>Osmotic fragility</subject><subject>Osmotic Fragility - drug effects</subject><subject>P branes</subject><subject>Peroxides - biosynthesis</subject><subject>Peroxides - metabolism</subject><subject>Peroxides - pharmacology</subject><subject>Photochemistry</subject><subject>Photolysis</subject><subject>Porphyrias - blood</subject><subject>Porphyrias - metabolism</subject><subject>Protoporphyrins</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkFFPwyAUhYnRzDn9By7hybdOKBTaR7M4ZzLjYvSZUKApS1sqdIn999Js0ScI55x7Dx8AS4xWGKfsMShrOmVWmBcringeXwm-AHOMiiwpUkQuwRwhwpIc8ewa3IRwQChqBZmBGWV5kWI-B-26do0Jg_GugdtRe9fH64_VBm6cb-VgXQdtBz-MhmvTNPDNtKWXnQlQdhruaze42rSuGYMNk_HZj0MdpzhrBqvg3kdD73xfj97KW3BVySaYu_O5AF-b58_1Ntm9v7yun3aJIhkbkqqUhCpSEkWlprE1y7BOsa4wzmhFMWNa85KXRaYUS1HFMoZyXspS0QrzmFyAh9Pc3rvvY_yeaG1QsX4s7o5B5DhPSYp4NGYno_IuBG8q0XvbSj8KjMSEWZwxi4hZTJjFhDnmlucFx7I1-i915hr1-5N-CIPz_0M5oUVByC9LXYbW</recordid><startdate>19730316</startdate><enddate>19730316</enddate><creator>Lamola, A. A.</creator><creator>Yamane, T.</creator><creator>Trozzolo, A. M.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19730316</creationdate><title>Cholesterol Hydroperoxide Formation in Red Cell Membranes and Photohemolysis in Erythropoietic Protoporphyria</title><author>Lamola, A. A. ; Yamane, T. ; Trozzolo, A. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-fba34c3b3c4ad4000651d21df1154f4166dd7b7b95cc620f656087babc4f174c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Carbon Isotopes</topic><topic>Cell Membrane - metabolism</topic><topic>Cholesterol - metabolism</topic><topic>Cholesterol - pharmacology</topic><topic>Cholesterols</topic><topic>Chromosomes</topic><topic>Convulsants</topic><topic>Enzymes</topic><topic>Erythrocytes - cytology</topic><topic>Erythrocytes - metabolism</topic><topic>Hemolysis</topic><topic>Humans</topic><topic>Hybridity</topic><topic>Liposomes</topic><topic>Osmotic fragility</topic><topic>Osmotic Fragility - drug effects</topic><topic>P branes</topic><topic>Peroxides - biosynthesis</topic><topic>Peroxides - metabolism</topic><topic>Peroxides - pharmacology</topic><topic>Photochemistry</topic><topic>Photolysis</topic><topic>Porphyrias - blood</topic><topic>Porphyrias - metabolism</topic><topic>Protoporphyrins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lamola, A. A.</creatorcontrib><creatorcontrib>Yamane, T.</creatorcontrib><creatorcontrib>Trozzolo, A. M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lamola, A. A.</au><au>Yamane, T.</au><au>Trozzolo, A. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cholesterol Hydroperoxide Formation in Red Cell Membranes and Photohemolysis in Erythropoietic Protoporphyria</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1973-03-16</date><risdate>1973</risdate><volume>179</volume><issue>4078</issue><spage>1131</spage><epage>1133</epage><pages>1131-1133</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>3β-Hydroxy-5α-hydroperoxy-$\Delta ^{6}$-cholestene is produced in protoporphyrin-containing red blood cell ghosts irradiated with approximately 400-nanometer light in the presence of oxygen. Incorporation of this cholesterol photooxidation product into normal red blood cells leads to increased osmotic fragility and eventual hemolysis. These results may be relevant to photohemolysis associated with erythropoietic protoporphyria.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>4689217</pmid><doi>10.1126/science.179.4078.1131</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1973-03, Vol.179 (4078), p.1131-1133 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81823207 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Carbon Isotopes Cell Membrane - metabolism Cholesterol - metabolism Cholesterol - pharmacology Cholesterols Chromosomes Convulsants Enzymes Erythrocytes - cytology Erythrocytes - metabolism Hemolysis Humans Hybridity Liposomes Osmotic fragility Osmotic Fragility - drug effects P branes Peroxides - biosynthesis Peroxides - metabolism Peroxides - pharmacology Photochemistry Photolysis Porphyrias - blood Porphyrias - metabolism Protoporphyrins |
| title | Cholesterol Hydroperoxide Formation in Red Cell Membranes and Photohemolysis in Erythropoietic Protoporphyria |
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