Cholesterol Hydroperoxide Formation in Red Cell Membranes and Photohemolysis in Erythropoietic Protoporphyria

3β-Hydroxy-5α-hydroperoxy-$\Delta ^{6}$-cholestene is produced in protoporphyrin-containing red blood cell ghosts irradiated with approximately 400-nanometer light in the presence of oxygen. Incorporation of this cholesterol photooxidation product into normal red blood cells leads to increased osmot...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1973-03, Vol.179 (4078), p.1131-1133
Hauptverfasser:	Lamola, A. A., Yamane, T., Trozzolo, A. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon Isotopes Cell Membrane - metabolism Cholesterol - metabolism Cholesterol - pharmacology Cholesterols Chromosomes Convulsants Enzymes Erythrocytes - cytology Erythrocytes - metabolism Hemolysis Humans Hybridity Liposomes Osmotic fragility Osmotic Fragility - drug effects P branes Peroxides - biosynthesis Peroxides - metabolism Peroxides - pharmacology Photochemistry Photolysis Porphyrias - blood Porphyrias - metabolism Protoporphyrins
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Beschreibung
Zusammenfassung:	3β-Hydroxy-5α-hydroperoxy-$\Delta ^{6}$-cholestene is produced in protoporphyrin-containing red blood cell ghosts irradiated with approximately 400-nanometer light in the presence of oxygen. Incorporation of this cholesterol photooxidation product into normal red blood cells leads to increased osmotic fragility and eventual hemolysis. These results may be relevant to photohemolysis associated with erythropoietic protoporphyria.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.179.4078.1131