Sexual precocity attributable to ectopic gonadotropin secretion by hepatoblastoma
Described here is a male child with sexual precocity attributable to the secretion of an ectopic gonadotropin by an hepatoblastoma. The interstitial cell stimulating properties of the ectopic gonadotropin are shown by biologic neutralization tests to correspond more closely to those of human pituita...
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| Veröffentlicht in: | The American journal of medicine 1973-03, Vol.54 (3), p.390-403 |
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| container_title | The American journal of medicine |
| container_volume | 54 |
| creator | McArthur, Janet W. Toll, Giles D. Russfield, Agnes B. Reiss, Alice M. Quinby, William C. Baker, William H. |
| description | Described here is a male child with sexual precocity attributable to the secretion of an ectopic gonadotropin by an hepatoblastoma. The interstitial cell stimulating properties of the ectopic gonadotropin are shown by biologic neutralization tests to correspond more closely to those of human pituitary interstitial cell stimulating hormone than to those of human chorionic gonadotropin. The clinical and pathologic features in this case are compared with those of the 10 other known cases, and the pathologic physiology is discussed. |
| doi_str_mv | 10.1016/0002-9343(73)90034-X |
| format | Article |
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The interstitial cell stimulating properties of the ectopic gonadotropin are shown by biologic neutralization tests to correspond more closely to those of human pituitary interstitial cell stimulating hormone than to those of human chorionic gonadotropin. The clinical and pathologic features in this case are compared with those of the 10 other known cases, and the pathologic physiology is discussed.</description><identifier>ISSN: 0002-9343</identifier><identifier>EISSN: 1555-7162</identifier><identifier>DOI: 10.1016/0002-9343(73)90034-X</identifier><identifier>PMID: 4347570</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>17-Hydroxycorticosteroids - urine ; 17-Ketosteroids - urine ; Carcinoma, Hepatocellular - drug therapy ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - physiopathology ; Child, Preschool ; Dactinomycin - therapeutic use ; Estrogens - urine ; Ethinyl Estradiol - therapeutic use ; Gonadotropins - metabolism ; Hormones, Ectopic - metabolism ; Humans ; Liver - pathology ; Liver Neoplasms - drug therapy ; Liver Neoplasms - pathology ; Liver Neoplasms - physiopathology ; Luteinizing Hormone - urine ; Male ; Neutralization Tests ; Puberty, Precocious - drug therapy ; Puberty, Precocious - etiology ; Testosterone - urine</subject><ispartof>The American journal of medicine, 1973-03, Vol.54 (3), p.390-403</ispartof><rights>1973</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-6fb0fe4a4a7b259e9e9b421616576dffa23571c8a3204a0a19f84b98de6044d83</citedby><cites>FETCH-LOGICAL-c357t-6fb0fe4a4a7b259e9e9b421616576dffa23571c8a3204a0a19f84b98de6044d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/000293437390034X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65308</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4347570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McArthur, Janet W.</creatorcontrib><creatorcontrib>Toll, Giles D.</creatorcontrib><creatorcontrib>Russfield, Agnes B.</creatorcontrib><creatorcontrib>Reiss, Alice M.</creatorcontrib><creatorcontrib>Quinby, William C.</creatorcontrib><creatorcontrib>Baker, William H.</creatorcontrib><title>Sexual precocity attributable to ectopic gonadotropin secretion by hepatoblastoma</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>Described here is a male child with sexual precocity attributable to the secretion of an ectopic gonadotropin by an hepatoblastoma. The interstitial cell stimulating properties of the ectopic gonadotropin are shown by biologic neutralization tests to correspond more closely to those of human pituitary interstitial cell stimulating hormone than to those of human chorionic gonadotropin. The clinical and pathologic features in this case are compared with those of the 10 other known cases, and the pathologic physiology is discussed.</description><subject>17-Hydroxycorticosteroids - urine</subject><subject>17-Ketosteroids - urine</subject><subject>Carcinoma, Hepatocellular - drug therapy</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - physiopathology</subject><subject>Child, Preschool</subject><subject>Dactinomycin - therapeutic use</subject><subject>Estrogens - urine</subject><subject>Ethinyl Estradiol - therapeutic use</subject><subject>Gonadotropins - metabolism</subject><subject>Hormones, Ectopic - metabolism</subject><subject>Humans</subject><subject>Liver - pathology</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - physiopathology</subject><subject>Luteinizing Hormone - urine</subject><subject>Male</subject><subject>Neutralization Tests</subject><subject>Puberty, Precocious - drug therapy</subject><subject>Puberty, Precocious - etiology</subject><subject>Testosterone - urine</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMo67r6DRR6Ej1UkyZt04sgi_9gQUSFvYUknWqkbWqSivvtzbqLR5nD8Jg3b5gfQscEXxBMikuMcZZWlNGzkp5XGFOWLnfQlOR5npakyHbR9M-yjw68_4gSV3kxQRNGWZmXeIqenuF7lG0yONBWm7BKZAjOqDFI1UISbAI62MHo5M32srbBRdEnHrSDYGyfqFXyDoMMVrXSB9vJQ7TXyNbD0bbP0Ovtzcv8Pl083j3MrxeppnkZ0qJRuAEmmSxVllcQS7GMFKTIy6JuGplFG9Fc0gwziSWpGs5UxWsoMGM1pzN0uskdnP0cwQfRGa-hbWUPdvSCE55lnNNoZBujdtZ7B40YnOmkWwmCxZqkWGMSa0yipOKXpFjGtZNt_qg6qP-Wtuji_Gozh_jklwEnvDbQa6hNZBlEbc3_B34Ad-2Dzw</recordid><startdate>197303</startdate><enddate>197303</enddate><creator>McArthur, Janet W.</creator><creator>Toll, Giles D.</creator><creator>Russfield, Agnes B.</creator><creator>Reiss, Alice M.</creator><creator>Quinby, William C.</creator><creator>Baker, William H.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197303</creationdate><title>Sexual precocity attributable to ectopic gonadotropin secretion by hepatoblastoma</title><author>McArthur, Janet W. ; Toll, Giles D. ; Russfield, Agnes B. ; Reiss, Alice M. ; Quinby, William C. ; Baker, William H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-6fb0fe4a4a7b259e9e9b421616576dffa23571c8a3204a0a19f84b98de6044d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>17-Hydroxycorticosteroids - urine</topic><topic>17-Ketosteroids - urine</topic><topic>Carcinoma, Hepatocellular - drug therapy</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - physiopathology</topic><topic>Child, Preschool</topic><topic>Dactinomycin - therapeutic use</topic><topic>Estrogens - urine</topic><topic>Ethinyl Estradiol - therapeutic use</topic><topic>Gonadotropins - metabolism</topic><topic>Hormones, Ectopic - metabolism</topic><topic>Humans</topic><topic>Liver - pathology</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - physiopathology</topic><topic>Luteinizing Hormone - urine</topic><topic>Male</topic><topic>Neutralization Tests</topic><topic>Puberty, Precocious - drug therapy</topic><topic>Puberty, Precocious - etiology</topic><topic>Testosterone - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McArthur, Janet W.</creatorcontrib><creatorcontrib>Toll, Giles D.</creatorcontrib><creatorcontrib>Russfield, Agnes B.</creatorcontrib><creatorcontrib>Reiss, Alice M.</creatorcontrib><creatorcontrib>Quinby, William C.</creatorcontrib><creatorcontrib>Baker, William H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McArthur, Janet W.</au><au>Toll, Giles D.</au><au>Russfield, Agnes B.</au><au>Reiss, Alice M.</au><au>Quinby, William C.</au><au>Baker, William H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sexual precocity attributable to ectopic gonadotropin secretion by hepatoblastoma</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>1973-03</date><risdate>1973</risdate><volume>54</volume><issue>3</issue><spage>390</spage><epage>403</epage><pages>390-403</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><abstract>Described here is a male child with sexual precocity attributable to the secretion of an ectopic gonadotropin by an hepatoblastoma. The interstitial cell stimulating properties of the ectopic gonadotropin are shown by biologic neutralization tests to correspond more closely to those of human pituitary interstitial cell stimulating hormone than to those of human chorionic gonadotropin. The clinical and pathologic features in this case are compared with those of the 10 other known cases, and the pathologic physiology is discussed.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>4347570</pmid><doi>10.1016/0002-9343(73)90034-X</doi><tpages>14</tpages></addata></record> |
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| ispartof | The American journal of medicine, 1973-03, Vol.54 (3), p.390-403 |
| issn | 0002-9343 1555-7162 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 17-Hydroxycorticosteroids - urine 17-Ketosteroids - urine Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - physiopathology Child, Preschool Dactinomycin - therapeutic use Estrogens - urine Ethinyl Estradiol - therapeutic use Gonadotropins - metabolism Hormones, Ectopic - metabolism Humans Liver - pathology Liver Neoplasms - drug therapy Liver Neoplasms - pathology Liver Neoplasms - physiopathology Luteinizing Hormone - urine Male Neutralization Tests Puberty, Precocious - drug therapy Puberty, Precocious - etiology Testosterone - urine |
| title | Sexual precocity attributable to ectopic gonadotropin secretion by hepatoblastoma |
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