Nitroglycerin Sublingual Tablets I: Stability of Conventional Tablets

Nitroglycerin in molded sublingual tablets volatilizes and undergoes intertablet migration. Consequently, tablets that are uniform when manufactured develop enough intertablet dose variation that they frequently fail the USP XVIII content uniformity test. Factors influencing volatilization and migra...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1973-01, Vol.62 (1), p.122-129
1. Verfasser:	Fusari, Salvatore A.
Format:	Artikel
Sprache:	eng
Schlagworte:	and intertablet migration Autoanalysis Content uniformity Content uniformity, nitroglycerin tablets—volatilization and intertablet migration Drug Packaging Drug Stability Drug Storage Mouth Floor Nitroglycerin - analysis Nitroglycerin tablets-stability nitroglycerin tablets-volatilization and intertablet migration Nitroglycerin tablets—stability, volatilization, and intertablet migration nitroglycerin-stability Placebos Tablets Tablets - analysis Tablets, nitroglycerin—stability, volatilization, and intertablet migration Temperature Time Factors volatilization
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Nitroglycerin in molded sublingual tablets volatilizes and undergoes intertablet migration. Consequently, tablets that are uniform when manufactured develop enough intertablet dose variation that they frequently fail the USP XVIII content uniformity test. Factors influencing volatilization and migration are discussed.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600620125