Enhanced Hepatic Microsomal Activity by Pretreatment of Rats with Acetone or Isopropanol

Summary Rat liver microsomes isolated from rats pretreated orally with acetone or isopropanol possessed an enhanced capacity to bind 14CCl4 and 14CHCl3 covalently and to demethylate DMN. The N-demethylation of ethylmorphine was unchanged by this pretreatment. Since there was no increase in the level...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1973-01, Vol.142 (1), p.237-240
Hauptverfasser:	Sipes, I. Glenn, Stripp, Bitten, Krishna, Gopal, Maling, Harriet M., Gillette, James R.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Propanol - pharmacology Acetone - pharmacology Animals Carbon Isotopes Carbon Tetrachloride - metabolism Chloroform - metabolism Cytochrome P-450 Enzyme System - metabolism Cytochrome Reductases - metabolism Male Microsomes, Liver - drug effects Microsomes, Liver - enzymology Microsomes, Liver - metabolism Morphine - metabolism NAD - metabolism NADP - metabolism Nitrosamines - metabolism Protein Binding Rats
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Zusammenfassung:	Summary Rat liver microsomes isolated from rats pretreated orally with acetone or isopropanol possessed an enhanced capacity to bind 14CCl4 and 14CHCl3 covalently and to demethylate DMN. The N-demethylation of ethylmorphine was unchanged by this pretreatment. Since there was no increase in the level of microsomal protein, and microsomal cytochrome P-450 or the activity of NADPH-cytochrome c reductase, the mechanism of this enhanced metabolism remains unclear. The authors acknowledge the excellent technical assistance of E. M. Boykins, M. A. Williams and W. Saul.
ISSN:	0037-9727 1535-3702 1535-3699
DOI:	10.3181/00379727-142-36996