Visceral manifestations of American mucocutaneous leishmaniasis

1. 1. Two cases of American mucocutaneous leishmaniasis with visceral manifestations are presented. These are the second and third cases of the mucosal variety of the disease to have been reported from Panama, emphasizing the rare occurrence of this disease in this area. 2. 2. Systemic involvement was manifested by hepatosplenomegaly, hyperglobulinemia, abnormal liver function tests and cellular infiltration of the liver. 3. 3. It is believed that the separation into two distinct forms of mucocutaneous leishmaniasis (Sudan and American) based on clinical features is invalid. 4. 4. Antimony treatment (fuadin) succeeded in ameliorating the disease without producing a complete cure in one case. 5. 5. It is recommended that 2-hydroxystilbamidine be given further trial in the treatment of mucocutaneous leishmaniasis.