Isolation of RNA Virus from Papillary Tumors of the Human Renal Pelvis

Virus particles were detected by electron microscopy in three papillary cancers of the human renal pelvis. Similar particles were seen in cells from all three tumors in primary culture. An RNA virus was isolated from these tumors. The serum of tumor patients contains neutralizing antibodies against...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1973-01, Vol.179 (4071), p.393-395
Hauptverfasser:	Elliott, Arthur Y., Fraley, Elwin E., Cleveland, Patrick, Castro, Anthony E., Stein, Nell
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Viral - analysis Carbon Isotopes Carcinoma, Transitional Cell - microbiology Cell culture techniques Cells, Cultured Centrifugation, Density Gradient Cultured cells Cultured tumor cells Cytopathogenic Effect, Viral Epithelial cells Fibroblasts Humans Kidney Kidney cells Kidney Neoplasms - microbiology Kidney Pelvis Kidneys Male Microscopy, Electron Neutralization Tests Orotic Acid - metabolism Retroviridae - isolation & purification RNA viruses RNA Viruses - enzymology RNA Viruses - immunology RNA Viruses - isolation & purification RNA Viruses - metabolism RNA-Directed DNA Polymerase - analysis Templates, Genetic Testis Tumors Virions Viruses
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Beschreibung
Zusammenfassung:	Virus particles were detected by electron microscopy in three papillary cancers of the human renal pelvis. Similar particles were seen in cells from all three tumors in primary culture. An RNA virus was isolated from these tumors. The serum of tumor patients contains neutralizing antibodies against virus isolated from two of the tumors. Initial studies suggest that this agent is not a known human RNA virus.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.179.4071.393