A METHOD FOR MEASURING MENTAL PERFORMANCE IN THE ELDERLY AND ITS USE IN A PILOT CLINICAL TRIAL OF MECLOFENOXATE IN ORGANIC DEMENTIA (PRELIMINARY COMMUNICATION)

A small double-blind study of the effect of meclofenoxate (Lucidril) on the mental ability of a sample of elderly patients in two short-stay geriatric units was undertaken using an objective measure of performance in the form of an automatically administered ‘learning’ task. Twelve patients, all wom...

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Veröffentlicht in:	Age and ageing 1972-05, Vol.1 (2), p.74-80
Hauptverfasser:	GEDYE, J. L., EXTON-SMITH, A. N., WEDGWOOD, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - therapeutic use Administration, Oral Aged Central Nervous System Stimulants - therapeutic use Clinical Trials as Topic Dementia - drug therapy Female Humans Learning - drug effects Male Meclofenoxate - pharmacology Meclofenoxate - therapeutic use Mental Processes - drug effects Neurocognitive Disorders - drug therapy Paired-Associate Learning - drug effects Placebos Programmed Instruction as Topic Task Performance and Analysis
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Beschreibung
Zusammenfassung:	A small double-blind study of the effect of meclofenoxate (Lucidril) on the mental ability of a sample of elderly patients in two short-stay geriatric units was undertaken using an objective measure of performance in the form of an automatically administered ‘learning’ task. Twelve patients, all women, in six matched pairs, completed the study in accordance with the trial design criteria. The treated group all improved with respect to their controls (P = 0·025, one tail), a result which is regarded as encouraging and warranting further work on both the assessment technique used and the effects of meclofenoxate.
ISSN:	0002-0729 1468-2834
DOI:	10.1093/ageing/1.2.74