A Simple Test for Erythropoietin in Deproteinized Plasma Extract.

Summary and Conclusions A simple test for erythropoietin in deproteinized plasma extract is described. A total of 3 or 4 days is required for subcutaneous injection of the plasma extract and only one intravenous injection of Fe59 is necessary. When concentrated plasma extracts are given to hypophy-sectomized rats, 6 to 9 fold differences in response between anemic and control groups are achieved. The deproteinized nature of the material enables cross-species examination of the erythropoietic factor.